Evidence map›Paper›PMID 42505135›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Heat Stress Promotes Fibroblast-Derived WNT5A Secretion Through m

Yuanyuan Wan, Yaqing Wen, Yushan Zhang, Lan Zhang, Jianjian Zhu, Zhen Tang, Ling Jiang, Chuhan Fu, Shu Zhou, Keyi Zhang and 4 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yuanyuan WanDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.ORCID https://orcid.org/0009-0002-9475-1464
Yaqing WenDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.ORCID https://orcid.org/0009-0006-7410-4832
Yushan ZhangDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.ORCID https://orcid.org/0000-0002-9979-6621
Lan ZhangDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Jianjian ZhuMedical Education Center of Jinan University, Guangzhou, People's Republic of China.ORCID https://orcid.org/0000-0002-0538-0343
Zhen TangDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.ORCID https://orcid.org/0000-0003-2354-5014
Ling JiangDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.ORCID https://orcid.org/0000-0001-5082-097X
Chuhan FuDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.ORCID https://orcid.org/0000-0003-0116-4675
Shu ZhouDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Keyi ZhangDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.ORCID https://orcid.org/0009-0000-9253-7646
Jiangfeng HuangDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Li LeiDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Jing ChenDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Qinghai ZengDepartment of Dermatology, Third Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.ORCID https://orcid.org/0000-0002-6747-1486

Funding

Fundamental Research Funds for the Central Universities of the Central South University 2026ZZTS0102Health Research Project of Hunan Provincial Health Commission 20256824High level Health Talents in Hunan Province 20240304082Natural Science Foundation of Hunan Province 2024JJ7010
6 · The paper itself

Abstract

As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident. Growing clinical evidence suggests that heat stress can induce cutaneous hyperpigmentation. However, the underlying mechanisms remain incompletely understood. In this study, we demonstrate that heat stress promotes repigmentation in vitiligo lesions and induces melanogenesis in depigmented mouse skin. Mechanistically, we reveal that heat stress upregulates WNT5A expression and paracrine secretion in dermal fibroblasts (FB) through METTL3-mediated N

Indexed as

fzd10heat stressmelanogenesisn6‐methyladenosineparacrine functionwnt5a

Identifiers

PMID42505135
PMCPMC13403720

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.