Evidence map›Paper›PMID 42506449›Full record

ArticleMetabolites2026

Metabolomic Profiling Has the Potential to Differentiate Between Iron Deficiency Anemia and Anemia of Inflammation.

Triin Paabo, Eliis Grigor, Egon Taalberg, Natalja Luppova, Eliise-Rosalinda Raudmäe, Piret Mihkelson, Alan Altraja, Ain Kaare, Rando Porosk, Kalle Kilk

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In one paragraph

Article in Metabolites, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Triin PaaboDepartment of Hematology and Bone Marrow Transplant, Tartu University Hospital, 50406 Tartu, Estonia.
Eliis GrigorDepartment of Biochemistry, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411 Tartu, Estonia.
Egon TaalbergDepartment of Biochemistry, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411 Tartu, Estonia.
Natalja LuppovaDepartment of Hematology and Bone Marrow Transplant, Tartu University Hospital, 50406 Tartu, Estonia.
Eliise-Rosalinda RaudmäeUnited Laboratories, Tartu University Hospital, 50406 Tartu, Estonia.
Piret MihkelsonUnited Laboratories, Tartu University Hospital, 50406 Tartu, Estonia.
Alan AltrajaLung Clinic, Tartu University Hospital, 50406 Tartu, Estonia.ORCID 0000-0001-7798-9871
Ain KaareDepartment of Hematology and Bone Marrow Transplant, Tartu University Hospital, 50406 Tartu, Estonia.ORCID 0000-0002-3170-1016
Rando PoroskDepartment of Biochemistry, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411 Tartu, Estonia.
Kalle KilkDepartment of Biochemistry, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411 Tartu, Estonia.ORCID 0000-0003-4551-9466

Funding

Estonian Research Council PRG1437European Union 2014-2020.4.01.15-0012
6 · The paper itself

Abstract

BACKGROUND/

objectivesDiscrimination between iron deficiency anemia (IDA) and anemia of inflammation (AI), the major causes of anemia, remains a challenge and novel biomarkers are needed. This prospective study characterizes metabolomic changes in patients with anemia, compares IDA and AI, and evaluates the ability of metabolomic profiling to categorize otherwise unclassifiable anemia (UA) cases.

methodsIn the single-center cross-sectional study, patients with anemia were classified as IDA, AI, or their combination (IDA + AI) according to traditional iron biomarkers. Targeted metabolomic analysis was conducted with tandem mass spectrometry using the MxP

resultsThe final cohort included 70 patients with anemia and 27 controls. The concentrations of six metabolites and six calculated parameters were significantly different in patients with anemia compared to controls. Anemia was associated with decreased concentrations of several polyunsaturated fatty acid (PUFA)-containing triglycerides (

conclusionsMetabolomic markers of PUFAs differ between patients with anemia and controls, indicating possible alterations in lipid metabolism. Our preliminary findings suggest that metabolomic data may be capable of distinguishing between IDA and AI. However, owing to several limitations of the current study, the potential utility of metabolome-based approaches should be confirmed in independent validation studies.

Indexed as

anemia of inflammationbiomarkersiron deficiencymetabolomics

Identifiers

PMID42506449
PMCPMC13414310

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.