ReviewJournal of neural transmission (Vienna, Austria : 1996)2026
Ferroptosis in depression: mechanisms, association, and therapeutic strategies.
Review in Journal of neural transmission (Vienna, Austria : 1996), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Depression is a highly disabling mental disorder, and the existing treatments have limitations. The development of new drugs is urgently needed. Ferroptosis, as a regulated form of cell death mediated by iron-dependent phospholipid peroxidation, is closely related to the pathological process of depression. In patients with depression and depression models, there are phenomena such as iron metabolism disorders, enhanced lipid peroxidation, and downregulation of anti-ferroptotic molecules like GPX4, etc. These processes involve the GPX4-GSH system, mitochondrial function, autophagy, etc., in the occurrence of the disease. Antioxidants targeting ferroptosis, iron chelators, and single or compound components of traditional Chinese medicine can improve depressive symptoms by inhibiting ferroptosis. This article reviews the mechanism of ferroptosis, its association with depression, and related treatment strategies, providing a new perspective for the study of depression mechanisms and drug development.
Indexed as
Identifiers
42507173What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.