ArticleMolecular biology reports2026
Biofilm disruption by citronellol and geraniol against clinical uropathogenic Pseudomonas aeruginosa: an integrated in vitro and in silico investigation.
Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAntimicrobial resistance (AMR) by Pseudomonas aeruginosa, within urinary tract and nosocomial infections, involves biofilm formation and quorum sensing (QS) constituting a major clinical challenge.
methodsThe chemical composition of Pelargonium graveolens essential oil (EO) was determined by gas chromatography-mass spectrometry (GC-MS). Antibacterial activity of the EO and its major constituents, citronellol and geraniol, was evaluated against clinical and reference P. aeruginosa strains using disk diffusion and broth microdilution assays. Antibiofilm activity was assessed at concentrations ranging from 2×MIC to sub-MIC levels. Interference with quorum-sensing-associated phenotypes was investigated using Chromobacterium violaceum CV12472 and CV026 biosensor strains. Swarming and swimming motility assays were performed. Molecular docking and ADMET analyses were conducted to explore potential target interactions and pharmacokinetic properties.
resultsCitronellol (34.29%) and geraniol (18.62%) were the predominant constituents of the EO. Antibacterial activity yielded inhibition zones of 10-14 mm and MIC values ranging from 1% to 0.031% (v/v), with geraniol showing the lowest MIC (0.031%). The EO, citronellol, and geraniol inhibited biofilm formation, reaching 87.28% inhibition at 2×MIC while retaining activity at sub-MIC concentrations. All treatments reduced violacein production in C. violaceum biosensors and inhibited bacterial motility, with maximum reductions of 82.6% (swarming) and 74.3% (swimming). Geraniol generally exhibited the strongest activity. Docking analysis revealed binding affinities of - 6.08 and - 5.83 kcal/mol for citronellol and geraniol, respectively.
conclusionP. graveolens EO, citronellol, and geraniol exhibited promising anti-virulence properties against multidrug-resistant uropathogenic P. aeruginosa, supporting their potential as complementary agents for controlling biofilm- and motility-associated infections.
Indexed as
Identifiers
42507230What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.