ArticleEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2026
Skin keratin correlates with bone and tendon collagen quality: a proof-of-concept clinical study using FTIR spectroscopy in shoulder arthroplasty patients.
Article in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Letter to the Editor regarding "Skin keratin correlates with bone and tendon collagen quality: a proof-of-concept clinical study using FTIR spectroscopy in shoulder arthroplasty patients".European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Article
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9 authors.
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Abstract
backgroundThere is a current need for non-invasive approaches to clinically assess the quality of bone and tendon tissues. We hypothesize that skin keratin properties correlate with those of collagen in tendon and bone.
methodsEight clinical patients undergoing shoulder arthroplasty were enrolled. We applied Fourier-transform-infrared(FTIR) spectroscopy to evaluate whether superficial skin composition reflected tendon and bone quality. Resultant data was analyzed for peak intensities and ratios reflecting the tissue content of specific molecules.
resultsIn-situ FTIR spectra of skin showed peaks assigned to keratin and keratin/lipid content in the stratum corneum. Ex-vivo spectra of harvested bone and tendon showed peaks reflecting collagen quality and quantity, as well as tissue mineralization in bone. Significant correlations were observed between the content of keratin-specific FTIR signal in the skin and collagen quality in bone(r = 0.72;p < 0.05) and tendon(r = 0.76;p < 0.05), as well as between collagen quality in bone and tendon(r = 0.89;p < 0.05). Moreover, a correlation was found between the keratin/lipid content in skin and the degree of bone tissue mineralization(r = 0.70;p = 0.053).
conclusionsThis preliminary study highlights the potential of FTIR assessment of skin as a non-invasive approach to assess bone and tendon quality, which could provide a cost-effective and non-invasive tool to aid in counseling patients considering musculoskeletal treatment.
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