Evidence map›Paper›PMID 42507268›Full record

ReviewInflammopharmacology2026

Transient receptor potential vanilloid channels in inflammatory bowel diseases: linking inflammation, angiogenesis, and oxidative stress.

Peihong Li, Yikun Zhang, Siqing Guo, Hongyi Hu, TingJun Cheng, Kexin Zeng, Tingting Zhang, Linda Zhong, Jiang Lin, Boyun Sun

Abstract readReview
PubMed Publisher
In one paragraph

Review in Inflammopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Peihong LiDepartment of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Yikun ZhangFengxian District Hospital of Traditional Chinese Medicine, Shanghai, 201499, China.
Siqing GuoDepartment of Proctology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Hongyi HuDepartment of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
TingJun ChengWenzhou Hospital of Traditional Chinese Medicine, Zhejiang Chinese Medical University, Wenzhou, 325000, Zhejiang, China.
Kexin ZengHunan Agricultural University, Changsha, 410128, Hunan, China.
Tingting ZhangDepartment of Colorectal Surgery, Shanghai Yangpu Hospital of Traditional Chinese Medicine, Shanghai, 200438, China.
Linda ZhongSchool of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore.
Jiang LinDepartment of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Boyun SunDepartment of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China. sunby131@foxmail.com.

Funding

Science and Education Special Project of the China Joint Graduate School of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences grant number: CI2023C020LH
6 · The paper itself

Abstract

Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is characterized by chronic relapsing intestinal inflammation driven by complex interactions among immune dysregulation, epithelial barrier disruption, vascular dysfunction, oxidative stress, and gut microbiota imbalance. Despite advances in biologic and small-molecule therapies, a substantial proportion of patients remain refractory to treatment or experience significant adverse effects, underscoring the need for novel mechanistic insights and therapeutic targets. Emerging evidence suggests that the Transient Receptor Potential Vanilloid (TRPV) channel family may represent one of several potential integrative nodes of neurogenic inflammation, immune activation, microvascular dysfunction, epithelial injury, and redox imbalance in IBD. Transient Receptor Potential Vanilloid (TRPV) channels are broadly expressed in intestinal epithelial cells, immune cells, sensory neurons, and vascular endothelial cells, where they regulate Ca

Indexed as

AngiogenesisInflammationInflammatory Bowel DiseasesNeovascularization, PathologicOxidative StressTRPV Cation ChannelsAnimalsHumansTRPV Cation ChannelsAngiogenesisCrohn’s diseaseInflammatory bowel diseaseOxidative stressTRPV channelsUlcerative colitis

Identifiers

PMID42507268

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.