ReviewClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2026
Microbiome-guided cancer immunotherapy: immune mechanisms, resistance pathways, and translational opportunities for precision oncology.
Review in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gut microbiome is increasingly recognized as a modulator of tumor-immune interactions and has been associated with cancer development, progression, and therapeutic response, while direct causal evidence remains strongest in mechanistic and interventional models. Microbial composition and metabolites, including SCFAs, bile acids, inosine, and tryptophan-derived products, may shape host immunity by influencing the tumor microenvironment (TME) and systemic immune responses, although the strength of evidence varies by model system and clinical context. These microbial signals have been linked to changes in T cells, B cells, NK cells, and MDSCs, with mechanistic studies supporting effects on cytokine networks, immune checkpoint signaling, inflammation, and antitumor immunity. Emerging translational evidence indicates that specific microbial signatures may serve as predictive biomarkers for immunotherapy efficacy, resistance, and treatment-related toxicity. In parallel, microbiome-targeted strategies, including FMT, probiotics, prebiotics, dietary modulation, and engineered microbial therapeutics, are being investigated as adjunctive approaches to improve cancer therapy, but their clinical efficacy remains incompletely validated. Understanding microbiome-immune crosstalk may therefore support precision oncology by identifying tractable microbial targets for improving therapeutic outcomes, overcoming immune-mediated treatment resistance, and guiding patient stratification across diverse cancer types and settings in clinical oncology practice.
Indexed as
Identifiers
42507333What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.