ArticleBMJ open respiratory research2026
EASE-CF: dietitian-led weight-loss intervention for adults with cystic fibrosis and excess weight: protocol for a feasibility randomised controlled trial.
Article in BMJ open respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
introductionAdvances in cystic fibrosis (CF) care have coincided with an increasing prevalence of excess body weight in this population, which may contribute to cardiometabolic and respiratory morbidity. However, evidence to guide intentional weight loss in this population is limited and safety concerns remain due to the established positive association between body weight and lung function. Delivering weight-loss interventions in CF is likely to be complex because of CF-specific factors, high treatment burden and embedded dietary advice focused on high-energy, high-fat diets for weight gain. To inform the design of a future definitive randomised controlled trial (RCT), we plan to test the feasibility, acceptability and safety of a dietitian supported weight-loss intervention compared with routine care. METHODS AND ANALYSIS: This multicentre feasibility RCT with an embedded qualitative study, will recruit 30 adults with CF and body mass index ≥27 kg/m ETHICS AND DISSEMINATION: Ethical approval has been granted by the National Research Ethics Service South Central B Research Ethics Committee (ref: 25/SC/0323). Findings will be disseminated through stakeholder engagement, conference presentations and publication in open-access, peer-reviewed journals. TRIAL REGISTRATION NUMBER: ISRCTN17298282.
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