ArticleThe Journal of pharmacology and experimental therapeutics2026
Preclinical pharmacology of N-pyrrolidino "nitazene" opioids appearing in nonmedical drug markets.
Article in The Journal of pharmacology and experimental therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
N-pyrrolidino (PYR) nitazenes are a subset of 2-benzylbenzimidazole opioids appearing in illicit drug markets, but there is limited information about the pharmacology of these compounds. Here, we examined the opioid-like effects of PYR nitazenes with varying alkoxy chain lengths (ie, methoxy, ethoxy, propoxy, and isopropoxy) compared with fentanyl. Opioid receptor binding and functional assays were employed to determine affinities and potencies of the compounds in vitro. Acute opioid-like effects were examined in mice, using hot plate antinociception, motor activity, and body temperature measures. PYR nitazenes displayed high affinity at the μ-opioid receptor (K
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