Trial reportScientific reports2026
Individual variability in hydrogen-producing microbes influences the response to hydrogen supplementation on sleep quality: a randomized, double-blind, placebo-controlled, parallel study.
Trial report in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Hydrogen has been reported to exert antioxidant and anti-inflammatory effects, and its potential health benefits have been investigated. However, to our knowledge, evidence regarding its impact on sleep quality in healthy individuals remains extremely limited. In addition, the influence of inter-individual variability in the gut microbiota on hydrogen efficacy has seldom been studied. In this study, we aimed to assess the impact of hydrogen-rich jelly on sleep quality and examine the influence of gut microbiota on this effect. A total of 44 healthy adults with poor sleep quality were randomized to receive either hydrogen-rich jelly or placebo jelly. No significant differences were observed between the intervention groups in the changes in sleep-related outcomes, including OSA-MA, VAS, PSQI, and STAI scores, in the overall analysis. Notably, when participants were stratified by the mean change in the VAS score for sleep quality, gut microbiota β-diversity showed apparent clustering in the hydrogen group but not in the placebo group. This cluster was explained by the differences in the relative abundance of hydrogen-producing bacteria, such as Bacteroides. Linear mixed-effects model analyses revealed significant interaction effects in the group × H
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