Evidence map›Paper›PMID 42509433›Full record

ArticleBulletin of experimental biology and medicine2026

Comparative Analysis of the Pharmacokinetic Characteristics of 2,6-Diisobornyl-4-Methylphenol and Its Metabolites in Rat Bile under Normal Conditions and in Liver Pathology.

G A Frelikh, E A Yanovskaya, A P Lakeev, G A Chernysheva, V I Smolyakova, D V Tsuran, I Yu Chukicheva, A V Kutchin

Abstract readComparative Study
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

G A FrelikhGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia. galina_stykon@mail.ru.
E A YanovskayaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
A P LakeevGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
G A ChernyshevaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
V I SmolyakovaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
D V TsuranGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
I Yu ChukichevaInstitute of Chemistry, Komi Science Center, Ural Branch of the Russian Academy of Sciences, Syktyvkar, Russia.
A V KutchinInstitute of Chemistry, Komi Science Center, Ural Branch of the Russian Academy of Sciences, Syktyvkar, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied the pharmacokinetic characteristics of phenolic antioxidant 2,6-diisobornyl-4-methylphenol (IBP) and its metabolites in rat bile following intragastric administration at a dose of 10 mg/kg to rats with toxic liver injury induced by carbon tetrachloride and healthy animals. Bile samples from each animal were collected repeatedly to study the pharmacokinetics of IBP and its metabolites. The content of the analytes was assessed by HPLC-MS/MS. In rats with liver pathology, significant changes in the pharmacokinetic parameters of IBP (a significant decrease in C

Indexed as

AntioxidantsBileCamphanesChemical and Drug Induced Liver InjuryCresolsLiverAnimalsCarbon TetrachlorideChromatography, High Pressure LiquidMaleRatsRats, WistarTandem Mass Spectrometry4-methyl-2,6-diisobornylphenolAntioxidantsCamphanesCarbon TetrachlorideCresols2,6-diisobornyl-4-methylphenolbilelivermetabolismpharmacokinetics

Identifiers

PMID42509433

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.