Evidence map›Paper›PMID 42509665›Full record

Trial reportAlzheimer's & dementia : the journal of the Alzheimer's Association2026

CONNECT4 APOE: A randomized trial of telephone versus real-time two-way videoconference for disclosure of APOE genotype results in cognitively unimpaired adults.

Elisabeth McCarty Wood, Jessica B Langbaum, Brian L Egleston, Demetrios Ofidis, Cara Cacioppo, Carolyn M Langlois, Michelle Weinberg, Scott Y H Kim, Eric M Reiman, Pierre N Tariot and 3 more

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02978729 (A Randomized Study of Telephone Versus Videoconference Communication for Remote Genetic Disclosure in the APOE4 Trial), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02978729 nacompletednot on this map

A Randomized Study of Telephone Versus Videoconference Communication for Remote Genetic Disclosure in the APOE4 Trial

TypeinterventionalSponsorUniversity of PennsylvaniaRan2016 to 2019Enrolled613ConditionsAlzheimer Disease, Genetic Predisposition to DiseaseArmsTwo-way videoconference remote genetic counseling, Telephone remote genetic counseling
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Elisabeth McCarty WoodDepartment of Medicine, Division of Hematology-Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Jessica B LangbaumBanner Alzheimer's Institute, Phoenix, Arizona, USA.
Brian L EglestonFox Chase Cancer Center, Temple University, Philadelphia, Pennsylvania, USA.
Demetrios OfidisDepartment of Medicine, Division of Hematology-Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Cara CacioppoDepartment of Medicine, Division of Hematology-Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Carolyn M LangloisBanner Alzheimer's Institute, Phoenix, Arizona, USA.
Michelle WeinbergDepartment of Medicine, Division of Hematology-Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Scott Y H KimDepartment of Bioethics, NIH Clinical Center, Bethesda, Maryland, USA.
Eric M ReimanBanner Alzheimer's Institute, Phoenix, Arizona, USA.
Pierre N TariotBanner Alzheimer's Institute, Phoenix, Arizona, USA.
J Scott RobertsDepartment of Health Behavior and Health Equity, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Jason KarlawishDepartment of Medical Ethics and Health Policy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Angela R BradburyDepartment of Medicine, Division of Hematology-Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Funding

Alzheimer's AssociationBanner Alzheimer's FoundationF-Prime Biomedical Research Initiative (FBRI)GHR FoundationNIA NIH HHS 1UF1AG046150Novartis Pharma AG, Basel, Switzerland, and Amgen, Thousand Oaks, CA, USA
6 · The paper itself

Abstract

introductionData are needed to inform best practices for disclosing apolipoprotein E (APOE) results given increasing indications for testing.

methodsCONNECT4, a multi-center, randomized trial (NCT02978729) compared disclosure of APOE genotype by videoconference or telephone among cognitively unimpaired adults 60-75 years of age. Outcomes were collected at baseline, 2-7 days, 6 weeks, and 6 months.

resultsA total of 301 participants were randomized to telephone and 297 to videoconference disclosure. There were no significant differences between arms for primary or secondary patient-reported outcomes. Moderator analyses found that videoconference reduced depressive symptoms more for older participants (70-75 year), whereas teleconference reduced depressive symptoms more for younger participants (60-64 years) and videoconference increased knowledge for non-White participants as compared to White participants. DISCUSSION: These data suggest that both telephone and videoconference are reasonable options for disclosure of APOE genotype in cognitively unimpaired individuals. Videoconference disclosure may have some benefits for certain demographic groups.

Indexed as

Apolipoproteins ETelephoneVideoconferencingAgedDepressionFemaleGenotypeHumansMaleMiddle AgedReturn of Individual Research ResultsApolipoproteins EAPOEgenetic counselinggenetic testingtelehealth

Identifiers

PMID42509665
PMCPMC13408020

What Socratic holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.