Evidence map›Paper›PMID 42509765›Full record

Trial reportBiomolecules2026

Does Metformin Interfere with Cardiorespiratory and Substrate Oxidation Adaptations to Exercise Training in Metabolic Syndrome Patients? A Randomized Placebo-Controlled Trial.

Jabeur Methnani, Amira Moussa, Wissem Dhahbi, Halil İbrahim Ceylan, Ismail Dergaa, Aymen ElHraiech, Taieb Ach, Imed Latiri, Monia Zaouali, Ali Bouslama and 3 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jabeur MethnaniHigh Institute of Sport and Physical Education of Ksar Said, University of Manouba, Manouba 2010, Tunisia.ORCID 0000-0002-1422-3059
Amira MoussaLR12SP11, Biochemistry Department, Sahloul University Hospital, Sahloul 4011, Tunisia.
Wissem DhahbiResearch Unit (UR22JS01), Sport Sciences, Health and Movement, High Institute of Sport and Physical Education of Kef, University of Jendouba, El Kef 7100, Tunisia.ORCID 0000-0001-6221-546X
Halil İbrahim CeylanPhysical Education of Sports Teaching Department, Faculty of Sports Sciences, Atatürk University, Erzurum 25030, Türkiye.ORCID 0009-0005-2214-4667
Ismail DergaaHigh Institute of Sport and Physical Education of Ksar Said, University of Manouba, Manouba 2010, Tunisia.ORCID 0000-0001-8091-1856
Aymen ElHraiechDepartment of Cardiology, Sahloul University Hospital, Sahloul 4011, Tunisia.ORCID 0009-0009-1325-7255
Taieb AchLR19ES09, Laboratory of Exercise Physiology and Physiopathology, from Integrated to Molecular, Biology, Medicine and Health, Faculty of Medicine of Sousse, Sousse 4002, Tunisia.ORCID 0000-0002-8387-8278
Imed LatiriLR12SP09, Heart Failure Research Laboratory, Farhat Hached University Hospital, Sousse 4000, Tunisia.ORCID 0000-0002-6074-4736
Monia ZaoualiLR19ES09, Laboratory of Exercise Physiology and Physiopathology, from Integrated to Molecular, Biology, Medicine and Health, Faculty of Medicine of Sousse, Sousse 4002, Tunisia.
Ali BouslamaLR12SP11, Biochemistry Department, Sahloul University Hospital, Sahloul 4011, Tunisia.
Valentina StefanicaDepartment of Physical Education and Sport, Faculty of Sciences, Physical Education and Informatics, National University of Science and Technology Politehnica Bucharest, Pitesti University Center, 060042 Pitesti, Romania.ORCID 0000-0003-4031-1412
Asma OmezzineLR12SP11, Biochemistry Department, Sahloul University Hospital, Sahloul 4011, Tunisia.ORCID 0000-0002-0537-5384
Ezdine BouhlelHigh Institute of Sport and Physical Education of Ksar Said, University of Manouba, Manouba 2010, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metformin and aerobic exercise are routinely co-prescribed in the management of metabolic syndrome, yet evidence regarding their interaction on cardiorespiratory fitness and substrate oxidation adaptations remains inconsistent. This study aimed to investigate the effects of combined metformin and aerobic training on peak oxygen uptake (VO

Indexed as

Adaptation, PhysiologicalExerciseMetabolic SyndromeMetforminAdultCardiorespiratory FitnessEnergy MetabolismFemaleHumansMaleMiddle AgedOxidation-ReductionOxygen ConsumptionMetforminaerobic exercise trainingbiguanidescardiorespiratory fitnessexercise–drug interactionfat oxidationmetabolic syndromemetforminrating of perceived exertion

Identifiers

PMID42509765
PMCPMC13407419

What Socratic holds

Texttitle and abstract
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.