ReviewDiagnostics (Basel, Switzerland)2026
Pleomorphic Adenomas and Their Atypical Morphology: Pitfalls in the Diagnosis of Salivary Gland Tumors.
Review in Diagnostics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Pleomorphic adenomas (PAs) are benign mixed tumors of the salivary glands that usually present with morphological characteristics consisting of epithelial and myoepithelial cells and a chondromyxoid stromal component. Atypical cells; squamous, osseous, lipomatous, endocrine-like or apocrine metaplasia; aspects of invasion (vascular, perineural, in adjacent tissues or the capsule); necrosis; and unusual dimensions were reported as uncommon aspects that can be encountered in PAs. This study consisted of a retrospective analysis of the morphological characteristics of PAs, aiming to identify their unusual features and prevent misdiagnosis. We discuss the diverse morphological aspects of PAs, with particular emphasis on the challenges associated with their diagnosis.
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