ReviewDiagnostics (Basel, Switzerland)2026
Why Radiomics Rarely Reaches the Clinic: Reproducibility, Validation, and Evidence Gap-A Critical Narrative Review.
Jacopo Pozzi, Jacopo D'Argenzio, Serena Carriero, Maurizio Cè, Dario D'Arrigo, Pierpaolo Biondetti, Carolina Lanza, Salvatore Alessio Angileri, Matilde Pavan, Rossella Catona and 1 more
Abstract readReview
In one paragraphReview in Diagnostics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Jacopo PozziPostgraduate School in Radiodiagnostics, Università degli Studi di Milano, 20122 Milan, Italy.ORCID 0009-0000-6564-6724 Jacopo D'ArgenzioPostgraduate School in Radiodiagnostics, Università degli Studi di Milano, 20122 Milan, Italy.ORCID 0009-0005-4218-3292 Serena CarrieroDepartment of Diagnostic and Interventional Radiology, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy.ORCID 0000-0003-2583-4215 Maurizio CèDepartment of Diagnostic and Interventional Radiology, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy.ORCID 0000-0002-8906-5665 Dario D'ArrigoPostgraduate School in Radiodiagnostics, Università degli Studi di Milano, 20122 Milan, Italy.ORCID 0009-0008-9601-6272 Pierpaolo BiondettiDepartment of Diagnostic and Interventional Radiology, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy.ORCID 0000-0002-2737-2053 Carolina LanzaDepartment of Diagnostic and Interventional Radiology, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy.
Salvatore Alessio AngileriDepartment of Diagnostic and Interventional Radiology, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy.
Matilde PavanPostgraduate School in Radiodiagnostics, Università degli Studi di Milano, 20122 Milan, Italy.ORCID 0009-0004-4374-7806 Rossella CatonaPostgraduate School in Radiodiagnostics, Università degli Studi di Milano, 20122 Milan, Italy.ORCID 0009-0005-3192-8295 Gianpaolo CarrafielloDepartment of Diagnostic and Interventional Radiology, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy.
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Radiomics has produced tens of thousands of publications yet almost no handcrafted radiomic signatures in routine clinical use, and the reasons are increasingly understood to be problems of reproducibility and clinical translation rather than of algorithms. This critical narrative review argues that the field systematically generates
Indexed as
clinical prediction modelsclinical translationdata leakageevidence-based radiologyexternal validationmeta-researchmethodological qualityradiomicsreporting guidelinesreproducibility
Identifiers
PMID42510129
PMCPMC13407916
What Socratic holds
Textmetadata
LicenceCC BY
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