Evidence map›Paper›PMID 42510225›Full record

ReviewBehavioral sciences (Basel, Switzerland)2026

The Impact of Childhood Trauma on Neuropsychological Disorders and Its Intergenerational Transmission Mechanisms.

Xuyan Cheng, Ping Liu, Qing Zhang

Abstract readReview
In one paragraph

Review in Behavioral sciences (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xuyan ChengSchool of Mental Health and Psychological Sciences, Anhui Medical University, Hefei 230032, China.
Ping LiuSchool of Mental Health and Psychological Sciences, Anhui Medical University, Hefei 230032, China.
Qing ZhangSchool of Mental Health and Psychological Sciences, Anhui Medical University, Hefei 230032, China.

Funding

Anhui Provincial Philosophy and Social Science Planning Project AHSKYQ2025D90the Natural Science Research Project of Anhui Educational Committee 2024AH050783
6 · The paper itself

Abstract

Childhood trauma is adversely linked to a spectrum of physical and neurobehavioral disorders, further facilitating the intergenerational transmission of familial trauma. This review systematically elaborates on the profound impacts of childhood trauma on both survivors and their descendants. It provides an in-depth analysis of the complex mechanisms underlying this intergenerational transmission, and innovatively proposes an Environmental-Psychological-Physiological-Molecular (EPPM) multilevel cross-generational interaction model. This model encompasses behavioral transmission of negative parenting, neural encoding of traumatic stress, intergenerational neurophysiological basis, biological permeation of the intrauterine environment, and mechanisms of epigenetic remodeling. This provides a scientific basis for deepening our understanding of the long-term consequences of trauma, promoting the development of early intervention strategies from an interdisciplinary perspective, and breaking the intergenerational cycle of trauma.

Indexed as

childhood traumaintergenerational transmissionneuropsychological disorders

Identifiers

PMID42510225
PMCPMC13405561

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.