Evidence map›Paper›PMID 42510544›Full record

ArticleAntioxidants (Basel, Switzerland)2026

Dietary Hydroxy-Selenomethionine Improves Antioxidant Status and Reduces Somatic Cell Count in Dairy Cows: Multi-Omics Insights into Rumen Microbiota and Metabolic Profiles.

Jiaxuan Song, Guanghuan Kong, Xinling Wang, Yunfei Zhai, Jiajie Wang, Jie Xu, Chongjun Li, Wudong Liu, Yaodi Han, Zhaoyu Han

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiaxuan SongCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Guanghuan KongPudong New Area Rural and Agricultural Affairs Commission, Shanghai 201299, China.
Xinling WangCollege of Animal Science and Food Engineering, Jinling Institute of Technology, Nanjing 210038, China.
Yunfei ZhaiCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.ORCID 0009-0002-6080-4396
Jiajie WangCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Jie XuCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Chongjun LiCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Wudong LiuCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Yaodi HanCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.ORCID 0009-0001-7964-8787
Zhaoyu HanCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-yielding dairy cows are highly susceptible to lactational oxidative stress, which compromises mammary barrier integrity and elevates mastitis risk. This study investigated the potential biological mechanisms by which dietary hydroxy-selenomethionine (HMSeBA) alleviates oxidative stress and improves health in dairy cows. Forty Holstein cows were assigned to a basal control group (0.32 mg Se/kg DM) or an HMSeBA-supplemented group (0.64 mg Se/kg DM) for 105 days. HMSeBA significantly enhanced selenium bioavailability in both milk and blood, comprehensively strengthening antioxidant defenses (increased glutathione peroxidase activity, decreased malondialdehyde) and elevated serum immunoglobulins (IgA, IgM, IgG), accompanied by a reduction in milk somatic cell count, without significantly affecting milk yield, feed intake, or milk production efficiency. Multi-omics analysis revealed that HMSeBA supplementation altered the rumen microenvironment by enriching fiber-degrading genera (

Indexed as

16S rRNA sequencingantioxidantdairy cowhydroxy-selenomethioninemetabolomics

Identifiers

PMID42510544
PMCPMC13405601

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.