Evidence map›Paper›PMID 42510552›Full record

ArticleAntioxidants (Basel, Switzerland)2026

Penicophenone F from an Arctic Fungus Against UVB-Induced Corneal Damage via Inhibiting the ROS-EphA2 Pathway.

Bo Hu, Jiansen Li, Shen Zhu, Zhe Ning, Yangyan Jin, Xiaoqiong Shi, Zexuan Zhang, Rui Liu, Xinyuan Wang, Lanbing Wu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Bo HuNaval Medical Center of PLA, Naval Medical University, Shanghai 200433, China.
Jiansen LiNaval Medical Center of PLA, Naval Medical University, Shanghai 200433, China.ORCID 0009-0000-1056-6866
Shen ZhuNaval Medical Center of PLA, Naval Medical University, Shanghai 200433, China.
Zhe NingNaval Medical Center of PLA, Naval Medical University, Shanghai 200433, China.
Yangyan JinNaval Medical Center of PLA, Naval Medical University, Shanghai 200433, China.
Xiaoqiong ShiChanghai Hospital, Naval Medical University, Shanghai 200433, China.ORCID 0000-0002-1149-788X
Zexuan ZhangNaval Medical Center of PLA, Naval Medical University, Shanghai 200433, China.
Rui LiuNaval Medical Center of PLA, Naval Medical University, Shanghai 200433, China.
Xinyuan WangNaval Medical Center of PLA, Naval Medical University, Shanghai 200433, China.
Lanbing WuNaval Medical Center of PLA, Naval Medical University, Shanghai 200433, China.
Yi CaoNaval Medical Center of PLA, Naval Medical University, Shanghai 200433, China.
Ying HeNaval Medical Center of PLA, Naval Medical University, Shanghai 200433, China.
Haobing YuNaval Medical Center of PLA, Naval Medical University, Shanghai 200433, China.

Funding

National Natural Science Foundation of China No. 82372100the National Key R&D Program of China No. 2024YFA1210100
6 · The paper itself

Abstract

Ultraviolet B (UVB) radiation-induced corneal injury poses a significant public health challenge. However, its underlying molecular mechanisms remain incompletely understood, hindering the development of effective interventions. This study identified a key molecular pathway in UVB-induced corneal damage, revealing that UVB exposure triggers a rapid intracellular burst of reactive oxygen species (ROS), which in turn upregulates and aberrantly activates the receptor tyrosine kinase Ephrin type-A receptor 2 (EphA2), thereby collectively accelerating DNA damage and photoaging in corneal epithelial cells. Based on this mechanism, we developed the natural compound Penicophenone F (PP-F), which was screened and identified from the Arctic fungus

Indexed as

Ephrin type-A receptor 2 (EphA2)Penicillium sp. MYA5Penicophenone Freactive oxygen speciesultraviolet B

Identifiers

PMID42510552
PMCPMC13406085

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.