Melatonin Attenuates Glucolipotoxicity-Induced Cardiac Oxidative Stress, Inflammation, Pyroptosis, and Fibrotic Remodeling in STZ/HFD-Treated ApoE

Chia-Hui Lin, I-Ning Tsai, Ai-Ting Jou, Chau-Jong Wang, Ming-Chih Chou, Hui-Pei Huang, Chien-Ning Huang

Abstract read

In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chia-Hui LinInstitute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.

I-Ning TsaiDepartment of Health Diet and Industry Management, Chung Shan Medical University, Taichung 402, Taiwan.ORCID 0009-0006-3508-2597

Ai-Ting JouInstitute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.

Chau-Jong WangDepartment of Health Diet and Industry Management, Chung Shan Medical University, Taichung 402, Taiwan.

Ming-Chih ChouInstitute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.

Hui-Pei HuangDepartment of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.

Chien-Ning HuangInstitute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.ORCID 0009-0009-5936-7900

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic cardiomyopathy (DCM) under glucolipotoxic stress is sustained by a reactive oxygen species (ROS)-driven circuit in which oxidative DNA damage and nitrosative injury prime NLR family pyrin domain containing 3 (NLRP3) inflammasome assembly, triggering caspase-1 activation, gasdermin D (GSDMD) cleavage, and pyroptotic cardiomyocyte death that propagates apoptosis and fibrotic remodeling. Whether melatonin can disrupt this oxidative-pyroptotic axis when both hyperglycemia and dyslipidemia coexist, the metabolic context most refractory to current therapy has not been established. Apolipoprotein E-deficient (ApoE

Indexed as

cardiac fibrosisdiabetic cardiomyopathyglucolipotoxicitymelatoninNLRP3 inflammasomeoxidative stresspyroptosis

Identifiers

PMID42510556

DOI10.3390/antiox15070825

PMCPMC13404163

What Socratic holds

Textmetadata

LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.