ArticleAntioxidants (Basel, Switzerland)2026
Comparison of HDL-Associated Antioxidant Activities and Anti-Inflammatory Effect Between Ozonated Sunflower Oil (OSO) and Ozonated Olive Oil (OOO) Under Carboxymethyllysine-Induced Acute Phase in Zebrafish Adults and Embryos.
Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study compares the efficacy of ozonated sunflower oil (OSO) and ozonated olive oil (OOO) in terms of antioxidant properties, modulation of high-density lipoprotein (HDL) functionality, and protective effects against carboxymethyllysine (CML)-mediated stress in zebrafish embryos and adults. The spectral and electronic nose (e-nose) analyses revealed that OSO and OOO possessed markedly distinct physicochemical characteristics and volatile and olfactory constituents compared with non-ozonated sunflower (SO) and olive oil (OO). The fluorescence spectrum analysis of HDL treated with OOO and OSO exhibited a red shift (2.6~3.3 nm) in the wavelength maximum fluorescence (WMF), accompanied by pronounced quenching of tryptophan fluorescence. Additionally, a significant increase in HDL-associated paraoxonase (PON) and ferric ion reduction (FRA) activity was observed in the OSO- and OOO-treated HDL. However, compared to OOO, significantly higher PON and FRA activities were observed in HDL treated with OSO. Also, compared to OOO, OSO effectively reverses CML-induced oxidative stress, altered heart rate, and reduced embryo survival. Similarly, in adult zebrafish, CML-compromised survival, swimming impairment, and disturbed antioxidant parameters were prevented by treatment with OOO and OSO. Nonetheless, OSO showed significantly higher efficacy than OOO. Consistently, OSO substantially reduced the CML-elevated blood glucose, total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) levels with a marked increase in high-density lipoprotein cholesterol (HDL-C) levels. Notably, no significant effect of OOO was observed on the reduction in and augmentation of LDL-C and HDL-C, respectively. Both OOO and OSO significantly protect against CML-triggered liver and kidney damage. However, compared with OOO, OSO significantly reduced neutrophil infiltration, interleukin-6 (IL-6) production, liver steatosis, ROS generation, and cellular senescence in the kidneys. The study concludes that OSO exerts significantly higher beneficial effects than OOO on HDL functionality and antioxidant defense, thereby attenuating CML-induced inflammatory and oxidative damage.
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