Curcumin Attenuates Glyphosate-Induced Mammary Toxicity via Suppression of ER Stress and the TNFα/MAPK/STAT3 Axis.

Yonglong He, Hanbing Yan, Zesheng Gan, Ziwei Cheng, Binyun Cao, Jiangang Wang, Xiaopeng An

Abstract read

In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yonglong HeCollege of Animal Science and Technology, Northwest A&F University, Yangling, Xianyang 712100, China.

Hanbing YanCollege of Animal Science and Technology, Northwest A&F University, Yangling, Xianyang 712100, China.

Zesheng GanCollege of Animal Science and Technology, Northwest A&F University, Yangling, Xianyang 712100, China.

Ziwei ChengCollege of Animal Science and Technology, Northwest A&F University, Yangling, Xianyang 712100, China.

Binyun CaoCollege of Animal Science and Technology, Northwest A&F University, Yangling, Xianyang 712100, China.

Jiangang WangCollege of Animal Science and Technology, Northwest A&F University, Yangling, Xianyang 712100, China.

Xiaopeng AnCollege of Animal Science and Technology, Northwest A&F University, Yangling, Xianyang 712100, China.

Funding

People's Government of Shaanxi Province 2024NC-ZDCYL-03-01, 2024NC-YBXM-082, 2024NC-GJHX-22 and 2025CY-JJQ-201People's Government of Shaanxi Province 2024ZY-CGZY-20 and 2024ZY-CGZY-22People's Government of Shaanxi Province 2025NYGG004 and QY-HS-2025A-01

6 · The paper itself

Abstract

Curcumin, a natural polyphenol with well-established antioxidant and anti-inflammatory properties, was evaluated for its protective effects against glyphosate (GLY)-induced mammary toxicity. Pregnant mice received GLY (50 or 250 mg/kg/day) with or without curcumin (150 mg/kg/day) by oral gavage; GLY dose-dependently disrupted alveolar architecture, caused marked inflammatory infiltration, and downregulated tight-junction proteins. In parallel, goat mammary epithelial cells (GMECs) were treated with GLY (1 or 7 mM) and curcumin (1 µM) to dissect acute cellular stress pathways. These complementary models address distinct aspects of GLY toxicity: the in vivo system reflects defined oral exposure, whereas the in vitro setting employs high concentrations to probe mechanistic events. Transcriptomic profiling combined with functional assays demonstrated that GLY triggered oxidative stress, endoplasmic reticulum stress, and intracellular Ca

Indexed as

apoptosiscurcuminglyphosateoxidative stresstoxicitytranscriptome

Identifiers

PMID42510624

DOI10.3390/antiox15070893

PMCPMC13406013

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.