Evidence map›Paper›PMID 42510658›Full record

ArticleBiology2026

Histone H3 Acetylation at

Godwin Sokpor, Pauline Antonie Ulmke, Hoang Duy Nguyen, Linh Pham, Princy Kakani, Van Trung Chu, Sebastian J Arnold, Beate Brand-Saberi, Huu Phuc Nguyen, Tran Tuoc

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Godwin SokporDepartment of Human Genetics, Ruhr University of Bochum, 44791 Bochum, Germany.ORCID 0000-0002-7120-0793
Pauline Antonie UlmkeDepartment of Human Genetics, Ruhr University of Bochum, 44791 Bochum, Germany.
Hoang Duy NguyenDepartment of Human Genetics, Ruhr University of Bochum, 44791 Bochum, Germany.
Linh PhamDepartment of Human Genetics, Ruhr University of Bochum, 44791 Bochum, Germany.
Princy KakaniDepartment of Human Genetics, Ruhr University of Bochum, 44791 Bochum, Germany.
Van Trung ChuMax Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.
Sebastian J ArnoldInstitute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.
Beate Brand-SaberiDepartment of Anatomy and Molecular Embryology, Institute of Anatomy, Medical Faculty, Ruhr University Bochum, 44801 Bochum, Germany.
Huu Phuc NguyenDepartment of Human Genetics, Ruhr University of Bochum, 44791 Bochum, Germany.ORCID 0000-0001-6139-788X
Tran TuocDepartment of Human Genetics, Ruhr University of Bochum, 44791 Bochum, Germany.ORCID 0000-0003-2079-7259

Funding

German Research Foundation AR 732/3-1German Research Foundation TU432/3-1German Research Foundation TU432/6-1Germany's Excellence Strategy CIBSS-EXC-2189-Project ID 390939984Ruhr University Bochum F1008N-20, IF-027N-22
6 · The paper itself

Abstract

Factors regulating the genesis and expansion of basal progenitor cell sub-populations, including intermediate progenitor cells, are critical determinants of cortical neurogenesis and brain growth. Epigenetic (chromatin) marks have emerged as notable regulators of cortical development. However, it is unclear how these factors specifically interact in the epigenome to orchestrate brain development. Here, we combined in vivo electroporation and a CRISPR-dead (d)Cas9 system to probe the contribution of a specific histone modification mark, H3K9ac (H3K9 acetylation), in the epigenome of isolated intermediate progenitor cells in developing mouse cortices. CRISPR-dCas9-mediated addition of H3K9ac at the promoter region of lncRNA

Indexed as

brain developmentCRISPR-dCas9epigenome editingH3K9 acetylationintermediate progenitorslncRNA Sox1ot

Identifiers

PMID42510658
PMCPMC13403965

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.