ArticleBiology2026
Immune Aging and Trauma Outcomes: Admission Inflammatory Profiles Consistent with Immunosenescence Are Associated with Excess One-Year Mortality Despite Similar in-Hospital Mortality in Older Adults with Multisystem Trauma.
Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
objectivesAging is associated with immunosenescence, which may alter the physiological response to trauma and influence long-term outcomes. This study aimed to compare clinical and laboratory parameters associated with in-hospital (iHM) and one-year mortality (OYM) between adult and geriatric patients with multisystem trauma and to explore laboratory findings consistent with immunosenescence in geriatric patients.
methodsIn this retrospective study, 345 patients with multisystem trauma were categorized into adult (
resultsAlthough iHM did not differ significantly between groups (
conclusionsDespite comparable in-hospital mortality, geriatric patients with multisystem trauma demonstrated significantly higher one-year mortality. The reduced post-traumatic inflammatory response observed in geriatric patients may be indicative of underlying immunosenescence and diminished immune reserve, thus emphasizing the necessity for age-specific prognostic models in trauma care.
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