Probiotics in Alleviating Constipation: Mechanisms, Strain Screening, and Applications.

Hao Zhong, Huange Zhang, Muhammad Hussain, Tong Hu, Sixian Chan, Rongfa Guan, Jian Li, Ningxiang Yu

Abstract readReview

In one paragraph

Review in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hao ZhongCollege of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China.

Huange ZhangCollege of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China.

Muhammad HussainCollege of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China.

Tong HuCollege of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China.ORCID 0000-0003-3814-8812

Sixian ChanCollege of Computer Science, Zhejiang University of Technology, Hangzhou 310023, China.

Rongfa GuanCollege of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China.

Jian LiKey Laboratory of Geriatric Nutrition and Health, Beijing Technology and Business University, Ministry of Education, Beijing 100048, China.

Ningxiang YuCollege of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China.

Funding

Key Technology Research and Development Program of Zhejiang Province No. 2023R5253National Natural Science Foundation of China No. 32402088"Pioneer" and "Leading Goose" R&D Program of Zhejiang No. 2024C04012the Cross-Innovation Open Project of Food Flavor and Health, Beijing Technology & Business University FFHCI-2026054

6 · The paper itself

Abstract

Constipation is a prevalent gastrointestinal disorder with limited effective therapeutic options. Probiotics have emerged as promising microecological interventions, yet marked strain-specific efficacy and incomplete mechanistic understanding hinder clinical translation. This review systematically synthesizes evidence from human randomized controlled trials, animal studies, and mechanistic investigations on probiotic interventions for constipation. We catalog major anti-constipation strains across

Indexed as

5-HTconstipationgut microbiotaprobioticsSCFAsscreening strategies

Identifiers

PMID42510758

DOI10.3390/biology15141212

PMCPMC13405705

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.