Nutrigenomics and Precision Nutrition in Inflammatory Bowel Disease.

Inflammatory bowel disease (IBD) represents a growing public health challenge worldwide, and its prevalence is increasing year by year. A growing body of evidence suggests that diet plays a key role in shaping the gut microbiota, whose dysbiosis is a significant component of IBD pathogenesis. In response to the limitations of traditional, one-size-fits-all dietary recommendations, the concept of precision nutrition is emerging, which involves tailoring nutrition to a patient's clinical, biological, and genetic characteristics. Of particular importance in this context is nutrigenomics, the science that studies the impact of dietary components on gene expression and the modulation of immune processes. Dietary components, such as polyphenols and certain vitamins, may influence gene expression and immune pathways. However, direct evidence that specific nutrients directly regulate genes associated with inflammatory bowel disease in humans remains limited. Nutrigenomic mechanisms reveal complex relationships between diet, gut microbiota, and genetic predispositions in IBD, encompassing transcriptome regulation, metabolomic changes, and epigenetic processes. A personalized nutritional approach, based on regular assessment of clinical and biological parameters and the close integration of dietary therapy with comprehensive treatment, appears to be a promising direction for the further development of IBD therapy.