ArticleGenes2026
Diabetic Hyperglycemia Induces Region-Specific Transcriptomic Remodeling in the Cochlea.
Article in Genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
objectivesDiabetes mellitus is associated with sensorineural hearing loss, but the cochlear molecular alterations related to this complication remain unclear. This pilot study aimed to characterize auditory function and region-specific transcriptomic changes in the diabetic cochlea.
methodsA streptozotocin-induced type 1 diabetic mouse model was established. Auditory function was assessed by auditory brainstem response (ABR) testing. Next-generation RNA sequencing was performed on micro-dissected cochlear regions, including the modiolus, lateral wall, and organ of Corti, followed by differential expression and gene ontology analyses.
resultsSTZ-induced diabetic mice showed elevated ABR thresholds compared with control mice. RNA sequencing revealed region-specific transcriptomic alterations across cochlear regions, with the lateral wall showing the greatest changes. Cross-region analysis identified a shared transcriptional signature consisting of 32 upregulated and 2 downregulated genes across the modiolus, lateral wall, and organ of Corti. Gene Ontology analysis showed enrichment of immune-related, inflammatory, metabolic stress-associated, and membrane-associated signaling.
conclusionsSTZ-induced diabetes was associated with ABR threshold elevation and shared as well as region-specific cochlear transcriptomic alterations in this mouse model. These findings provide a region-specific cochlear transcriptomic resource for diabetes-associated auditory dysfunction and support future studies using larger cohorts, independent molecular validation, histological assessment, and cell-type-resolved approaches.
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