ReviewCurrent issues in molecular biology2026
A Translational Review of Mechanisms of Effectiveness of Photobiomodulation on Somatosensory Neurons and the Peripheral Nervous System-From Molecular Mechanisms to Clinical Applications in Medicine and Dentistry.
Review in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review aims to provide a translational link between clinical evidence in the application of photobiomodulation for treatment of painful conditions in medicine and dentistry and neurophysiological effects of photobiomodulation therapy (PBMt). PBMt is gaining increasing acceptance as a therapeutic modality for pain management, particularly within dental practice. However, a clearer understanding of its mechanisms of action remains essential for broader clinical adoption and integration into mainstream healthcare. Central to the therapeutic effects of PBMt for pain is its interaction with neurons, which possess unique structural and functional characteristics. Advances in our understanding of the cellular architecture of dorsal root and trigeminal ganglion neurons highlight the importance of the stem axon and axon initial segment (AIS), a specialized region adjacent to the axon hillock that is now recognized as the principal site of action potential initiation. These developments have important implications for understanding the biological effects of PBMt and its clinical application. This review synthesizes evidence demonstrating that PBM influences cytoskeletal organization, mitochondrial structure and function, and intracellular signaling pathways, with downstream effects on neuronal excitability and nerve conduction. By integrating findings from cellular, neurophysiological, and clinical studies, the review examines how these mechanistic effects may contribute to pain modulation and analgesia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.