Evidence map›Paper›PMID 42511052›Full record

ArticleAnimals : an open access journal from MDPI2026

Analysis of circRNA Differential Expression and ceRNA Network Construction in Yak Mammary Glands Across Different Physiological Stages.

Zhenyu Zhang, Yongfu La, Xiaoming Ma, Xiaoyun Wu, Min Chu, Pengjia Bao, Xian Guo, Bo Yang, Chunnian Liang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhenyu ZhangKey Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Yongfu LaKey Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.ORCID 0000-0002-5659-4341
Xiaoming MaKey Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Xiaoyun WuKey Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Min ChuKey Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.
Pengjia BaoKey Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.ORCID 0000-0001-7671-1050
Xian GuoKey Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.ORCID 0000-0003-2390-4777
Bo YangZhangye Livestock Breeding and Improvement Station of Gansu Province, Zhangye 734000, China.
Chunnian LiangKey Laboratory of Yak Breeding Engineering of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.

Funding

Central Guidance Funds for Local Science and Technology Development Projects 25ZYJA008Key Talent Project of Gansu Province 2026RCXM096The Innovation Project of Chinese Academy of Agricultural Sciences 25-LIHPS-01The Modern Beef Yak Industry Technology System CARS-37
6 · The paper itself

Abstract

Yak is a distinctive domestic animal adapted to the Qinghai-Tibet Plateau, and its lactation performance is restricted by extreme high-altitude conditions. Despite the growing recognition of circRNAs as important regulators of mammary gland development in other species, no study has yet systematically investigated the stage-specific circRNA expression landscapes in yak mammary glands across gestation, lactation, and non-pregnant periods, or the potential ceRNA networks through which these circRNA may participate in regulating milk synthesis and mammary cell proliferation under high-altitude conditions. This study aimed to characterize circRNA expression features and lactation regulation in yak mammary glands at the gestation, lactation, and non-pregnant stages. Total RNA sequencing was performed on mammary specimens, followed by differential screening, functional enrichment, ceRNA network construction, and qPCR verification. Numerous stage-biased circRNAs were identified, among which

Indexed as

circular RNA (circRNA)competitive endogenous RNA (ceRNA) networkmammary glandRNA-seqyak

Identifiers

PMID42511052
PMCPMC13405935

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.