Field Trial Demonstrates Superiority of a Live Attenuated Vaccine for Integrated Control of

Changhua Lin, Yifei Xiang, Jiaxia Jiang, Yangzu Zhang, Hao Wang, Jiakang He

Abstract read

In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Changhua LinGuangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, College of Animal Science and Technology, Guangxi University, Nanning 530004, China.

Yifei XiangGuangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, College of Animal Science and Technology, Guangxi University, Nanning 530004, China.ORCID 0000-0002-7304-4915

Jiaxia JiangGuangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, College of Animal Science and Technology, Guangxi University, Nanning 530004, China.

Yangzu ZhangGuangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, College of Animal Science and Technology, Guangxi University, Nanning 530004, China.

Hao WangGuangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, College of Animal Science and Technology, Guangxi University, Nanning 530004, China.

Jiakang HeGuangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi Zhuang Autonomous Region Engineering Research Center of Veterinary Biologics, College of Animal Science and Technology, Guangxi University, Nanning 530004, China.

Funding

China Agriculture Research System CARS-35Guangxi Science and Technology Program Guike AB25069387, Guike AA24263033the Guangxi Agricultural Science and Technology Self-financed Project Z2024092the Internal Research Project of Guangxi State Farms Yongxin Animal Husbandry Group Yongxinmuke 2025012the National Modern Agricultural Industry Technology System Guangxi Innovation Team nycytxgxcxtd-2023-15-04

6 · The paper itself

Abstract

A field trial was conducted on a single commercial swine farm to compare the integrated control efficacy of an inactivated vaccine and a live attenuated vaccine against mycoplasmal pneumonia of swine (MPS). Mhp exposure in the herd was confirmed by qPCR prior to trial initiation. Initially, 30 five-day-old piglets were randomly assigned to three groups (10 piglets per group): non-immunized control, inactivated vaccine, and live attenuated vaccine, for clinical safety evaluation. Based on this, another 900 five-day-old piglets, confirmed Mhp-negative by antigen detection, were randomly allocated to three separate rearing zones (300 piglets per zone), with each zone randomly assigned to one of the three treatment groups. Parameters assessed included mucosal (sIgA) and serum (IgG) antibody levels, pulmonary inflammatory cytokine (e.g., IL-1β, IL-6, TNF-α) expression, lung lesion scores, and histopathological changes, with all evaluations performed by technicians blinded to group allocation. Growth performance and economic indicators were also recorded. Both vaccines exhibited favorable safety profiles. The live attenuated vaccine significantly enhanced nasal sIgA and serum IgG levels (

Indexed as

field trialinactivated vaccinelive attenuated vaccineMycoplasma hyopneumoniae

Identifiers

PMID42511128

DOI10.3390/ani16142252

PMCPMC13403539

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.