ArticleFoods (Basel, Switzerland)2026
Postharvest Aging and Harvest Stage Shape the Bioactive Profile, Hypolipidemic Activity, and Gut Microbiota-Modulating Effects of Citrus Peel Extracts in High-Fat-Diet-Fed Mice.
Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Citri Reticulatae Pericarpium (CRP), a citrus peel product derived from Citrus reticulata, is rich in flavonoids and polysaccharides, yet the effects of harvest stage and postharvest aging on its composition and metabolic functionality remain unclear. In this study, green CRP (CRP-Q) and red CRP (CRP-H) aged for 1, 3, or 5 years were extracted with 70% ethanol and evaluated in high-fat-diet (HFD)-fed mice. CRP-1Q contained the highest levels of hesperidin, nobiletin, and tangeretin, reaching 58.09 ± 0.91, 14.78 ± 0.18, and 9.15 ± 0.08 mg/g, respectively. These three flavonoids generally declined with aging, whereas longer-aged extracts showed more consistent hypolipidemic effects. CRP extracts reduced serum triglyceride and total cholesterol levels, attenuated hepatic steatosis and epididymal fat accumulation, and regulated lipid metabolism-related enzymes and genes, including FAS, ACC, HSL, LPL, SREBP-1c, HMGCR, PPAR-α, and PPAR-γ. Gut microbiota composition also changed in several aged-CRP groups, with Akkermansia abundance increasing alongside improved metabolic indicators. These findings suggest that aging duration, more than harvest stage, shaped the functional properties of CRP extracts, while the stronger activity of aged CRP was not explained by the three quantified flavonoids alone.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.