ArticleFoods (Basel, Switzerland)2026
Anti-Fatigue Effects of Donkey Milk and Its Polysaccharides in a Mouse Swimming Model.
Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Exercise-induced fatigue is a physiological limitation affecting athletic performance and recovery, driven by disrupted energy metabolism, oxidative stress, and inflammation. This study investigated the anti-fatigue effects of donkey milk and its polysaccharides in BALB/c mice using an exhaustive swimming model. Mice were randomly assigned to seven groups, including a negative control group and separate dose groups receiving donkey milk (2.08, 4.16, or 8.32 mL/kg) or donkey milk polysaccharides (0.625, 1.25, or 2.5 g/kg), for 30 days. Anti-fatigue activity was subsequently evaluated based on exhaustive swimming performance and fatigue-related biochemical parameters. Donkey milk polysaccharides, mainly composed of galactose, exhibited stronger in vitro antioxidant activity than donkey milk, which may be associated with their enhanced radical scavenging capacity. Both treatments significantly prolonged exhaustive swimming time (up to 2.27-fold,
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