Evidence map›Paper›PMID 42511449›Full record

ArticleInternational journal of molecular sciences2026

Unveiling and Benefits of Topically Applied l-(+)-Ergothioneine in Periwound Region.

Ladislav Šoltés, Anwar M Jardine, Csaba Biró, Karol Švík, Mojmír Mach, Katarína Valachová

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ladislav ŠoltésCentre of Experimental Medicine, Slovak Academy of Sciences, 84104 Bratislava, Slovakia.ORCID 0009-0002-1514-2258
Anwar M JardineFaculty of Science, Department of Chemistry, University of Cape Town, Cape Town 7701, South Africa.ORCID 0000-0002-8062-2736
Csaba BiróSt. Elizabeth Cancer Institute Hospital, 81250 Bratislava, Slovakia.
Karol ŠvíkCentre of Experimental Medicine, Slovak Academy of Sciences, 84104 Bratislava, Slovakia.ORCID 0000-0002-2642-7737
Mojmír MachCentre of Experimental Medicine, Slovak Academy of Sciences, 84104 Bratislava, Slovakia.ORCID 0000-0001-6958-1024
Katarína ValachováCentre of Experimental Medicine, Slovak Academy of Sciences, 84104 Bratislava, Slovakia.ORCID 0000-0002-8467-893X

Funding

Vedecká grantová agentúra MŠVVaM SR a SAV 2/0008/23
6 · The paper itself

Abstract

Oxidative stress significantly impairs wound healing by prolonging inflammation and damaging surrounding tissue. l-(+)-Ergothioneine (EGT), a naturally occurring thione-thiol antioxidant transported by OCTN1, exhibits potent cytoprotective and anti-inflammatory properties. The aim of the study was to investigate whether EGT applied topically to the periwound region can accelerate healing via transdermal antioxidant action. Full-thickness excisional wounds were created on the dorsum of Wistar rats. Animals were divided into three groups: the untreated rats (control), the rats treated with EGT at concentrations of 130 or 650 μg/cm

Indexed as

AntioxidantsErgothioneineWound HealingAdministration, CutaneousAdministration, TopicalAnimalsMaleOxidative StressRatsRats, WistarSkinAntioxidantsErgothioneinechronic inflammationHAT-hydrogen atom transferOCTN1 transporterthione-thiol compoundstransdermal delivery

Identifiers

PMID42511449
PMCPMC13410314

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.