Evidence map›Paper›PMID 42511526›Full record

ArticleInternational journal of molecular sciences2026

Immunochemotherapy with Amphotericin B and HisAK70 Vaccine for Cutaneous Leishmaniosis.

Socorro Espuelas, Carmen Palomino-Cano, Carlos Torrado-Salmerón, Helga K Ruiz, Paloma M de la Torre-Iglesias, Santiago Torrado-Santiago, Juan J Torrado, José María Alunda, Christophe Dardonville, Sergio Alberto Sánchez Guirales and 2 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Socorro EspuelasDepartment of Pharmaceutical Sciences, School of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain.ORCID 0000-0002-7352-1523
Carmen Palomino-CanoDepartment of Pharmaceutical Sciences, School of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain.ORCID 0000-0002-5523-4758
Carlos Torrado-SalmerónDepartment of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain.ORCID 0000-0002-4123-3367
Helga K RuizDepartment of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain.ORCID 0000-0003-2575-1233
Paloma M de la Torre-IglesiasDepartment of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain.ORCID 0000-0002-7768-0978
Santiago Torrado-SantiagoDepartment of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain.ORCID 0000-0002-3273-2615
Juan J TorradoDepartment of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain.ORCID 0000-0002-7823-1904
José María AlundaInstituto Universitario de Farmacia Industrial, Complutense University of Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain.ORCID 0000-0002-1491-8627
Christophe DardonvilleInstitute of Medicinal Chemistry (IQM-CSIC), 28006 Madrid, Spain.ORCID 0000-0001-5395-1932
Sergio Alberto Sánchez GuiralesDepartment of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain.ORCID 0000-0002-0331-0499
Dolores R SerranoDepartment of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain.ORCID 0000-0002-0475-8420
Javier CarriónGroup ICPVet, Department of Animal Health, Faculty of Veterinary Medicine, Complutense University of Madrid, 28040 Madrid, Spain.ORCID 0000-0001-7486-4942

Funding

Spanish Ministry of Science and Innovation PID2023-148406OB-I00
6 · The paper itself

Abstract

Cutaneous leishmaniosis (CL) remains a major neglected tropical disease, with current therapies constrained by toxicity, high cost, and variable efficacy. Here, we evaluated an immunochemotherapy strategy combining topical amphotericin B (AmB) with the therapeutic DNA vaccine HisAK70 in a murine model of

Indexed as

Amphotericin BAntiprotozoal AgentsImmunotherapyLeishmania majorLeishmaniasis, CutaneousVaccines, DNAAnimalsDisease Models, AnimalFemaleInterferon-gammaInterleukin-4MiceMice, Inbred BALB CParomomycinAmphotericin BAntiprotozoal AgentsInterferon-gammaInterleukin-4ParomomycinVaccines, DNAamphotericin Bcutaneous leishmaniosisdrug repurposingHisAK70immunochemotherapyparomomycinTh1 immune responsetherapeutic vaccinetopical therapy

Identifiers

PMID42511526
PMCPMC13410688

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.