Structural Modifications of Hybrid O-Alkylsulfonyl-β-(Benzimidazol-1-yl)propioamidoximes as a Pathway to the Antimicrobial, Antifungal and Antidiabetic Drugs.

Lyudmila Kayukova, Anna Vologzhanina, Ekaterina Dubasova, Roza Seidakhmetova, Azamat Yerlanuly, Aruzhan Sartoyeva, Aigul Malmakova

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Lyudmila KayukovaLaboratory of Chemistry of Synthetic and Natural Drug Substances, JSC A.B. Bekturov Institute of Chemical Sciences, 106 Shokan Ualikhanov Str., Almaty 050010, Kazakhstan.ORCID 0000-0002-1900-1228

Anna VologzhaninaX-Ray Diffraction Laboratory, A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow 119334, Russia.ORCID 0000-0002-6228-303X

Ekaterina DubasovaLaboratory of Quantum Chemistry, N.S. Kurnakov Institute of Inorganic and General Chemistry, Russian Academy of Sciences, Moscow 119991, Russia.ORCID 0009-0000-5165-6657

Roza SeidakhmetovaDepartment of Clinical Pharmacology and Evidence-Based Medicine, Karaganda Medical University, Karaganda 100012, Kazakhstan.ORCID 0000-0002-1990-4961

Azamat YerlanulyLaboratory of Chemistry of Synthetic and Natural Drug Substances, JSC A.B. Bekturov Institute of Chemical Sciences, 106 Shokan Ualikhanov Str., Almaty 050010, Kazakhstan.ORCID 0009-0009-5482-7621

Aruzhan SartoyevaLaboratory of Chemistry of Synthetic and Natural Drug Substances, JSC A.B. Bekturov Institute of Chemical Sciences, 106 Shokan Ualikhanov Str., Almaty 050010, Kazakhstan.

Aigul MalmakovaLaboratory of Chemistry of Synthetic and Natural Drug Substances, JSC A.B. Bekturov Institute of Chemical Sciences, 106 Shokan Ualikhanov Str., Almaty 050010, Kazakhstan.

Funding

Committee of Science of the Ministry of Science & High Education of the Republic of Kazakhstan IRN BR27101179

6 · The paper itself

Abstract

The continuous search for new chemical structures more active and less toxic than those currently in practice is justified on the basis of the use of proven pharmacophoric building blocks (benzimidazole heterocycle, sulfonyl group and amidoxime framework in our case). The aim of the work was to synthesize new O-alkylsulfonyl-β-(benzimidazol-1-yl)propioamidoximes and to test them for in vitro biological activities to identify potentially effective agents. Novel O-alkylsulfonylamidoximes were synthesized in hydrochloride and base forms by the reaction of β-(benzimidazol-1-yl)propioamidoxime with alkylsulfonyl chlorides AlkSO

Indexed as

Antifungal AgentsAnti-Infective AgentsBenzimidazolesHypoglycemic AgentsOximesFungiMicrobial Sensitivity TestsMolecular StructureStructure-Activity RelationshipamidoximeAntifungal AgentsAnti-Infective AgentsBenzimidazolesHypoglycemic AgentsOximesan amidoxime groupantifungal and antidiabetic activitiesbenzimidazole corehybridizationin vitro antimicrobialO-alkylsulfonyl moietyX-ray diffraction

Identifiers

PMID42511568

DOI10.3390/ijms27146224

PMCPMC13411167

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