Evidence map›Paper›PMID 42511576›Full record

ArticleInternational journal of molecular sciences2026

Comparative Analysis of Endothelial Cell Culture Models Under Altered Mechanical Conditions and Glucose Variations.

Augusta Volkevičiūtė, Jayashree Sahana, Estéfano Pinilla, Daniela Melnik, Luis Fernando González-Torres, Markus Wehland, Edgaras Stankevicius, Daniela Grimm, Ulf Simonsen

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Augusta VolkevičiūtėPreclinical Research Laboratory for Medicinal Products, Institute of Cardiology, Lithuanian University of Health Sciences, 50162 Kaunas, Lithuania.
Jayashree SahanaDepartment of Biomedicine, Pulmonary and Cardiovascular Pharmacology, Aarhus University, 8000 Aarhus, Denmark.
Estéfano PinillaDepartment of Biomedicine, Pulmonary and Cardiovascular Pharmacology, Aarhus University, 8000 Aarhus, Denmark.ORCID 0000-0002-7852-992X
Daniela MelnikDepartment of Microgravity and Translational Regenerative Medicine, Otto von Guericke University, 39106 Magdeburg, Germany.
Luis Fernando González-TorresDepartment of Microgravity and Translational Regenerative Medicine, Otto von Guericke University, 39106 Magdeburg, Germany.ORCID 0009-0001-3663-2953
Markus WehlandDepartment of Microgravity and Translational Regenerative Medicine, Otto von Guericke University, 39106 Magdeburg, Germany.ORCID 0000-0002-8160-859X
Edgaras StankeviciusPreclinical Research Laboratory for Medicinal Products, Institute of Cardiology, Lithuanian University of Health Sciences, 50162 Kaunas, Lithuania.ORCID 0000-0003-2210-708X
Daniela GrimmDepartment of Biomedicine, Pulmonary and Cardiovascular Pharmacology, Aarhus University, 8000 Aarhus, Denmark.ORCID 0000-0002-4991-3105
Ulf SimonsenPreclinical Research Laboratory for Medicinal Products, Institute of Cardiology, Lithuanian University of Health Sciences, 50162 Kaunas, Lithuania.ORCID 0000-0002-2169-7666

Funding

Novo Nordisk Foundation NNF24OC0096782Research Council of Lithuania The Role of Endothelial Transglutaminase-2 Signaling in Development of Neurovascular Dysfunction" (S-MIP-23-94)
6 · The paper itself

Abstract

Endothelial dysfunction is a defining feature of diabetic vascular disease and is characterized by impaired nitric oxide signaling, inflammatory activation, altered mechanotransduction, and disturbed angiogenic responses. The present study investigated whether hyperglycemia modulates endothelial phenotype in a model-dependent manner under distinct structural and mechanical culture conditions. EA.hy926 endothelial cells were cultured for 7 days under normoglycemic (5.5 mM) or high-glucose (25 mM) conditions as static monolayers (G-force = 1

Indexed as

Cell Culture TechniquesEndothelial CellsGlucoseAngiogenesisCadherin 5CadherinsCell AdhesionCell LineCollagenDrug CombinationsHumansHyperglycemiaLamininNitric Oxide Synthase Type IIIPhosphatidylinositol 3-KinasesProteoglycansCadherin 5CadherinsCollagenDrug CombinationsGlucoseLamininmatrigelNitric Oxide Synthase Type IIINOS3 protein, humanPhosphatidylinositol 3-KinasesProteoglycansProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesVascular Cell Adhesion Molecule-1Vascular Endothelial Growth Factor AVEGFA protein, humanVinculin3D clinostatangiogenesiscell adhesion moleculesendothelial cellshyperglycemiamulticellular spheroids

Identifiers

PMID42511576
PMCPMC13410307

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.