ArticleInternational journal of molecular sciences2026
A Spike-Linked HPV16 E7 DNA Vaccine Induces Potent Antitumor and Anti-Spike Immune Responses.
Yichu Xu, Yining Liu, Yu-Cheng Chang, Ya-Chea Tsai, Chuan-Hsiang Huang, Tzyy-Choou Wu, Chien-Fu Hung
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In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
7 authors.
Yichu XuDepartment of Pathology, Johns Hopkins University School of Medicine, 1550 Orleans Street, CRB II 307, Baltimore, MD 21287, USA.ORCID 0009-0002-5321-8284 Yining LiuDepartment of Pathology, Johns Hopkins University School of Medicine, 1550 Orleans Street, CRB II 307, Baltimore, MD 21287, USA.
Yu-Cheng ChangDepartment of Pathology, Johns Hopkins University School of Medicine, 1550 Orleans Street, CRB II 307, Baltimore, MD 21287, USA.
Ya-Chea TsaiDepartment of Pathology, Johns Hopkins University School of Medicine, 1550 Orleans Street, CRB II 307, Baltimore, MD 21287, USA.
Chuan-Hsiang HuangDepartment of Pathology, Johns Hopkins University School of Medicine, 1550 Orleans Street, CRB II 307, Baltimore, MD 21287, USA.ORCID 0000-0001-9993-8004 Tzyy-Choou WuDepartment of Pathology, Johns Hopkins University School of Medicine, 1550 Orleans Street, CRB II 307, Baltimore, MD 21287, USA.
Chien-Fu HungDepartment of Pathology, Johns Hopkins University School of Medicine, 1550 Orleans Street, CRB II 307, Baltimore, MD 21287, USA.
Funding
Treatment of HIV- and HIV+ Patients with HPV16+ CIN2/3 Using pNGLV4a-hCRTE6E7L2 DNA vaccine administered intramuscularly via electroporationP50CA098252 · NCI · JOHNS HOPKINS UNIVERSITY · PI RAPHAEL Paul VISCIDI · 2003 to 2026
$53.5MStrategies to Reduce Global Health Disparities in Cervical CancerR01CA295696 · NCI · JOHNS HOPKINS UNIVERSITY · PI TZYY-CHOOU WU · 2025 to 2026
$1.3MSalmonella derived nanoparticles for cancer immunotherapyR21DE034547 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI Chien-Fu Hung · 2025 to 2026
$450kNCI NIH HHS P50 CA098252NCI NIH HHS R01 CA295696NCI NIH HHS R01CA295696NCI NIH HHS R21DE034547NIDCR NIH HHS R21 DE034547NIH/NCI Specialized Program of Research Excellence (SPORE) in Cervical Cancer P50CA098252
6 · The paper itselfAbstract
Persistent infection with high-risk human papillomavirus (HPV), particularly HPV16, is a major driver of HPV-associated cancers; however, strategies for treating established HPV-induced tumors remain scarce. Here, we developed a DNA-based vaccine linking the SARS-CoV-2 spike (S) protein with an HPV16 E7 epitope (aa 49-57) to simultaneously induce antiviral humoral immunity and antitumor cellular responses. We generated 2 constructs, S-E7 and S-RE7, with the latter incorporating a furin cleavage site (R) to enhance antigen processing. In vitro, S-RE7 significantly enhanced E7-specific CD8
Indexed as
Cancer VaccinesHuman papillomavirus 16Papillomavirus E7 ProteinsPapillomavirus VaccinesSpike Glycoprotein, CoronavirusVaccines, DNAAnimalsCD8-Positive T-LymphocytesCOVID-19FemaleHumansImmunity, CellularMiceMice, Inbred C57BLPapillomavirus InfectionsSARS-CoV-2Cancer Vaccinesoncogene protein E7, Human papillomavirus type 16Papillomavirus E7 ProteinsPapillomavirus VaccinesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Vaccines, DNAcancerDNA vaccineimmunotherapyspike protein
Identifiers
PMID42511592
PMCPMC13410571
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