ArticleInternational journal of molecular sciences2026
Antielastase and Antihyaluronidase Activity of Isomangiferin, a Xanthone with Strong Antioxidant Properties.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Isomangiferin is a natural C-glycosylated xanthone, an isomer of mangiferin. The biological properties of isomangiferin are not clearly known. The antioxidant effect of this xanthone was assessed with 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and ferric-reducing antioxidant power (FRAP) tests. Isomangiferin's cytoprotective effects against menadione in human keratinocytes HaCaT were evaluated via an MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) test. Additionally, the inhibition of elastase and hyaluronidase by isomangiferin was tested spectrophotometrically. Antielastase activity was analyzed in silico and by evaluating the degradation of elastin fibers and elastin in tendons using image analysis. The results indicated that the antioxidant properties of the tested xanthone were stronger than those of ascorbic acid (the IC
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