Induction of Oxidative Stress on Retinal Pigment Epithelial Cells Triggered a Proangiogenic Environment.

Mohamed Abdouh, Alicia Goyeneche, Morgan Yurchuk, Miguel N Burnier

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mohamed AbdouhCancer Research Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.ORCID 0000-0003-0702-9335

Alicia GoyenecheCancer Research Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.

Morgan YurchukCancer Research Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.ORCID 0009-0007-4802-0448

Miguel N BurnierCancer Research Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dry age-related macular degeneration (AMD) can progress to wet AMD when leaking capillaries grow under the macula. Although rare, this transition holds significant risk as it causes more rapid and severe vision loss. Oxidative stress is damaging to cellular components and plays a pivotal role in chronic diseases. We aim to determine whether oxidative stress in retinal pigment epithelial (RPE) cells elicits a proangiogenic microenvironment. We exposed human primary RPE cells to hydrogen peroxide (H

Indexed as

AngiogenesisEpithelial CellsOxidative StressRetinal Pigment EpitheliumCells, CulturedCulture Media, ConditionedHumansHuman Umbilical Vein Endothelial CellsHydrogen PeroxideMacular DegenerationReactive Oxygen SpeciesVascular Endothelial Growth Factor ACulture Media, ConditionedHydrogen PeroxideReactive Oxygen SpeciesVascular Endothelial Growth Factor Aage-related macular degenerationangiogenesiscell culturedisease progressionhuman primary retinal pigment epithelial cellsoxidative stress

Identifiers

PMID42511632

DOI10.3390/ijms27146291

PMCPMC13409842

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.