ArticleInternational journal of molecular sciences2026
Hexaconazole-Induced Male Reproductive Toxicity Through ROS-Mediated Ferroptosis and Impaired Leydig Cell Steroidogenesis.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Triazole fungicides are ubiquitous environmental contaminants. However, their specific effects on the male reproductive system remain unclear. We investigated the toxicological effects of hexaconazole (HEX) on testicular function and elucidated its underlying molecular mechanisms. Although 8 weeks of HEX administration in mice did not affect body weight or gross testicular morphology, it significantly reduced sperm motility and circulating testosterone levels. Correspondingly, HEX exposure markedly downregulated germ cell (DDX4) and meiotic markers (SYCP3) as well as key steroidogenic related gene, including
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