Evidence mapPaperPMID 42511826Full record

ArticleInternational journal of molecular sciences2026

Empagliflozin, Linagliptin, and Metformin Differentially Affect Renal PI3K/Akt and MAPK/ERK Signaling Pathways in

Anton I Korbut, Elizaveta A Ananishnikova, Nikolai B Orlov, Nataliya P Bgatova, Natalia A Muraleva, Evgenii L Zavyalov, Vladimir I Konenkov, Vadim V Klimontov

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anton I KorbutResearch Institute of Clinical and Experimental Lymphology-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (RICEL-Branch of IC&G SB RAS), Novosibirsk 630117, Russia.ORCID 0000-0003-3502-5892
Elizaveta A AnanishnikovaResearch Institute of Clinical and Experimental Lymphology-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (RICEL-Branch of IC&G SB RAS), Novosibirsk 630117, Russia.
Nikolai B OrlovResearch Institute of Clinical and Experimental Lymphology-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (RICEL-Branch of IC&G SB RAS), Novosibirsk 630117, Russia.
Nataliya P BgatovaResearch Institute of Clinical and Experimental Lymphology-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (RICEL-Branch of IC&G SB RAS), Novosibirsk 630117, Russia.ORCID 0000-0002-4507-093X
Natalia A MuralevaInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IC&G SB RAS); Novosibirsk 630090, Russia.ORCID 0000-0002-0665-1723
Evgenii L ZavyalovInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IC&G SB RAS); Novosibirsk 630090, Russia.
Vladimir I KonenkovResearch Institute of Clinical and Experimental Lymphology-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (RICEL-Branch of IC&G SB RAS), Novosibirsk 630117, Russia.
Vadim V KlimontovResearch Institute of Clinical and Experimental Lymphology-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (RICEL-Branch of IC&G SB RAS), Novosibirsk 630117, Russia.

Funding

Research Institute of Clinical and Experimental Lymphology-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
6 · The paper itself

Abstract

Accumulating data indicate a role for the dysregulation of the cell cycle, autophagy and apoptosis in diabetic kidney disease. We aimed to evaluate the mediators of the PI3K/Akt and MAPK/ERK signaling pathways in the kidney of

Indexed as

Benzhydryl CompoundsDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2GlucosidesKidneyLinagliptinMAP Kinase Signaling SystemMetforminPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAnimalsDiabetic NephropathiesHypoglycemic AgentsMaleMiceSignal TransductionBenzhydryl CompoundsempagliflozinGlucosidesHypoglycemic AgentsLinagliptinMetforminPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktchronic kidney diseaseempagliflozinlinagliptinMAPK/ERK signalingmetforminPI3K/Akt signalingtype 2 diabetes

Identifiers

PMID42511826
PMCPMC13409939

What Socratic holds

Texttitle and abstract
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.