Evidence map›Paper›PMID 42511886›Full record

ReviewBiomedicines2026

Extracellular Vesicles as a Potential Tool in Cancer Diagnosis and Therapy.

Giovanni Citelli, Simone Peria, Sabina Di Matteo, Roberto Sirica, Federica Palmiero, Daniela Rita Vantaggiato, Rita Paola Debri, Raffaele Conte, Gianfranco Peluso

Abstract readReview
In one paragraph

Review in Biomedicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Giovanni CitelliFaculty of Medicine and Surgery, Saint Camillus International University of Health Sciences, Via di Sant'Alessandro 8, 00131 Rome, Italy.ORCID 0009-0005-0267-1187
Simone PeriaFaculty of Medicine and Surgery, Saint Camillus International University of Health Sciences, Via di Sant'Alessandro 8, 00131 Rome, Italy.ORCID 0009-0000-9579-3303
Sabina Di MatteoFaculty of Medicine and Surgery, Saint Camillus International University of Health Sciences, Via di Sant'Alessandro 8, 00131 Rome, Italy.ORCID 0000-0002-2586-7159
Roberto SiricaAMES Diagnostic Center, Via Padre Carmine Fico 24, 80013 Casalnuovo di Napoli, Italy.
Federica PalmieroDepartment of Biomedicine and Prevention, University of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.
Daniela Rita VantaggiatoFaculty of Medicine and Surgery, Saint Camillus International University of Health Sciences, Via di Sant'Alessandro 8, 00131 Rome, Italy.
Rita Paola DebriFaculty of Medicine and Surgery, Saint Camillus International University of Health Sciences, Via di Sant'Alessandro 8, 00131 Rome, Italy.
Raffaele ConteFaculty of Medicine and Surgery, Saint Camillus International University of Health Sciences, Via di Sant'Alessandro 8, 00131 Rome, Italy.ORCID 0000-0002-6266-4991
Gianfranco PelusoFaculty of Medicine and Surgery, Saint Camillus International University of Health Sciences, Via di Sant'Alessandro 8, 00131 Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer remains one of the leading causes of morbidity and mortality worldwide, with lung, breast, and colorectal cancers among the most prevalent and lethal malignancies. In recent years, extracellular vesicles (EVs) have emerged as important mediators of intercellular communication and promising tools in oncology. EVs are membrane-bound vesicles released by most cell types and carry diverse biomolecules, including nucleic acids, proteins, lipids, and metabolites derived from their parent cells. Their presence in biological fluids makes them attractive candidates for liquid biopsy applications and minimally invasive cancer diagnosis. In addition, EVs have gained considerable attention as therapeutic platforms due to their biocompatibility, stability, and ability to deliver functional cargo to recipient cells. Beyond mammalian EVs, plant-derived extracellular vesicles (PDEVs) are increasingly being investigated as scalable and potentially safe nanocarriers for biomedical applications. This review summarizes current advances in the use of EVs for cancer diagnosis and therapy, with particular emphasis on their role as biomarkers, drug-delivery systems, and emerging therapeutic agents. Furthermore, the review discusses current challenges and future perspectives related to EV isolation, characterization, and clinical translation in oncology.

Indexed as

cancer diagnosiscancer therapydrug deliveryextracellular vesiclesextracellular vesicles isolation methodsliquid biopsyplant-derived extracellular vesicles

Identifiers

PMID42511886
PMCPMC13405236

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.