Evidence map›Paper›PMID 42511943›Full record

ArticleBiomedicines2026

Melatonergic Modulation of SIRT1-Nrf2 Signaling Protects Against Doxorubicin-Induced Hepatic Injury in Rats.

Haluk Kerim Karakullukcu, Hatice Aygun, Murat Kalın, Mina Karakullukcu, Aylin Arslan, Serdar Savaş Gül, Ömer Faruk Özkan, Gülçin Ercan

Abstract read
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In one paragraph

Article in Biomedicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Haluk Kerim KarakullukcuDepartment of General Surgery, Sultan 2. Abdulhamid Han Educational and Research Hospital, University of Health Sciences, Istanbul 34668, Türkiye.ORCID 0000-0002-1180-8297
Hatice AygunNeuroscience Laboratory, BAMER, Biruni University, Istanbul 34015, Türkiye.ORCID 0000-0002-4272-0562
Murat KalınDepartment of General Surgery, Sultan 2. Abdulhamid Han Educational and Research Hospital, University of Health Sciences, Istanbul 34668, Türkiye.
Mina KarakullukcuDepartment of Oncology, Sultan 2. Abdulhamid Han Educational and Research Hospital, University of Health Sciences, Istanbul 34668, Türkiye.
Aylin ArslanDepartment of General Surgery, Istanbul Prof. Dr. Cemil Taşçıoğlu City Hospital, University of Health Sciences, Istanbul 34668, Türkiye.
Serdar Savaş GülDepartment of Nuclear Medicine, Faculty of Medicine, Lokman Hekim University, Ankara 06530, Türkiye.ORCID 0000-0003-4822-2588
Ömer Faruk ÖzkanDepartment of General Surgery, Sultan 2. Abdulhamid Han Educational and Research Hospital, University of Health Sciences, Istanbul 34668, Türkiye.
Gülçin ErcanDepartment of General Surgery, Sultan 2. Abdulhamid Han Educational and Research Hospital, University of Health Sciences, Istanbul 34668, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

agomelatinedoxorubicinhepatotoxicitymelatoninoxidative stressscintigraphic imagingSIRT1

Identifiers

PMID42511943
PMCPMC13405734

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.