ReviewBrain sciences2026
The Neutrophil-to-Lymphocyte Ratio in Fibromyalgia: A Systematic Review with a Neuroimmune Perspective.
Review in Brain sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesAlterations in systemic immune balance, reflected by changes in neutrophil and lymphocyte proportions, index a peripheral immune state relevant to central nervous system function. This systematic review and meta-analysis aimed to assess the differences in the neutrophil-to-lymphocyte ratio (NLR) between fibromyalgia patients and healthy controls and offer a framework to study fibromyalgia.
methodsWe adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and registered our work on PROSPERO (CRD420251001424). Two authors performed a comprehensive search of databases, including PubMed, Embase, Web of Science, and Scopus, until August 2025. The Newcastle-Ottawa Scale (NOS) was used for bias risk assessment, and STATA 19.0 software was used for statistical analyses. The standardized mean difference (SMD) and 95% confidence interval (CI) of the NLR were reported. Finally, 24 studies with 3143 fibromyalgia patients and 1610 healthy controls were included in our meta-analysis.
resultsThe results indicated that patients with fibromyalgia had elevated NLRs compared to healthy controls (SMD = 0.30; 95% CI = 0.07-0.52;
conclusionsOur meta-analysis supports the fact that the NLR is significantly different between patients with fibromyalgia and healthy controls. We conceptualize the idea that the NLR may be used as a "state-dependent" peripheral marker indexing the susceptibility of central nervous system sensitization, pain amplification, and responsiveness to future therapies.
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