Evidence mapPaperPMID 42513245Full record

ReviewJournal of clinical medicine2026

Gut Microbiota in Colorectal Cancer: Mechanisms of Carcinogenesis, Biomarkers, and Therapeutic Perspectives.

Bianca Andreea Cristinescu, Horatiu Dura, Sorin Radu Fleaca, Danusia Maria Onisor, Olga Brusnic, Corina Porr, Sabrina Birsan, Adrian Boicean

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bianca Andreea CristinescuMedical Clinical Department, Faculty of Medicine, "Lucian Blaga" University, 550024 Sibiu, Romania.ORCID 0009-0006-3137-1957
Horatiu DuraMedical Clinical Department, Faculty of Medicine, "Lucian Blaga" University, 550024 Sibiu, Romania.
Sorin Radu FleacaMedical Clinical Department, Faculty of Medicine, "Lucian Blaga" University, 550024 Sibiu, Romania.ORCID 0000-0002-2444-9828
Danusia Maria OnisorDepartment of Internal Medicine VII, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540136 Targu Mures, Romania.ORCID 0000-0002-5710-9109
Olga BrusnicDepartment of Internal Medicine VII, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540136 Targu Mures, Romania.
Corina PorrMedical Clinical Department, Faculty of Medicine, "Lucian Blaga" University, 550024 Sibiu, Romania.ORCID 0009-0000-7255-0835
Sabrina BirsanMedical Clinical Department, Faculty of Medicine, "Lucian Blaga" University, 550024 Sibiu, Romania.ORCID 0009-0007-7368-7674
Adrian BoiceanMedical Clinical Department, Faculty of Medicine, "Lucian Blaga" University, 550024 Sibiu, Romania.ORCID 0000-0002-6646-1585

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide, largely due to late-stage diagnosis and the limited sensitivity of current screening approaches for early lesions. In recent years, the gut microbiota has emerged as a key factor in colorectal carcinogenesis, offering promising opportunities for the development of novel, non-invasive diagnostic and therapeutic strategies. Specific bacterial species and microbial metabolites have been implicated in colorectal carcinogenesis and are under investigation as potential biomarkers for CRC detection. However, despite growing evidence of association, most remain investigational and require further clinical validation before routine implementation. Among the proposed bacterial biomarkers,

Indexed as

biomarkerscolorectal cancerdysbiosisgut microbiotametabolites

Identifiers

PMID42513245
PMCPMC13409873

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.