Evidence map›Paper›PMID 42513701›Full record

ArticleMaterials (Basel, Switzerland)2026

Novel Metformin-Containing Antibacterial Composite for Root Caries Restorations.

Ayman Altamimi, Ibrahim Ba-Armah, Heba Alqarni, Nader Almutairi, Yazeed Altamimi, Mohammad Alenizy, Abraham Schneider, Jirun Sun, Michael D Weir, Hockin H K Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ayman AltamimiDental Biomedical Sciences PhD Program, Graduate School, University of Maryland, Baltimore, MD 21201, USA.ORCID 0000-0003-3794-653X
Ibrahim Ba-ArmahDepartment of Restorative Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.ORCID 0000-0002-3524-2515
Heba AlqarniDental Biomedical Sciences PhD Program, Graduate School, University of Maryland, Baltimore, MD 21201, USA.
Nader AlmutairiDental Biomedical Sciences PhD Program, Graduate School, University of Maryland, Baltimore, MD 21201, USA.ORCID 0000-0002-7197-8239
Yazeed AltamimiDental Biomedical Sciences PhD Program, Graduate School, University of Maryland, Baltimore, MD 21201, USA.ORCID 0000-0001-9507-5416
Mohammad AlenizyDepartment of Restorative Dental Sciences, College of Dentistry, University of Hail, Hail 55475, Saudi Arabia.
Abraham SchneiderCollege of Dentistry, Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0001-8046-9789
Jirun SunADA Forsyth Institute, Cambridge, MA 02142, USA.ORCID 0000-0002-3383-8956
Michael D WeirDepartment of Biomaterials and Regenerative Dental Medicine, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA.ORCID 0000-0002-7961-3787
Hockin H K XuDepartment of Biomaterials and Regenerative Dental Medicine, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA.

Funding

Novel tunable metformin-releasing injectable scaffolds to enhance dental pulp stem cell-based craniofacial bone regenerationR01DE032692 · UNIVERSITY OF MARYLAND BALTIMORE · 2025 to 2025
$351k
NIDCR NIH HHS R01 DE032692University of Maryland School of Dentistry, NIH 1R01DE033442-01A1
6 · The paper itself

Abstract

backgroundTooth root caries and periodontal tissue loss remain major challenges in elderly and periodontally compromised patients, while current restorative materials lack combined antibacterial and regenerative properties.

objectiveThe objective of this study was to develop a novel metformin-containing antibacterial composite for root cavity restorations to prevent recurrent caries and potentially promote periodontal tissue regeneration.

methodsExperimental composites contained 5% dimethylaminohexadecyl methacrylate (DMAHDM), varying metformin concentrations (2.5-15%), and glass fillers. Mechanical and antibacterial properties as well as cytocompatibility toward human periodontal ligament stem cells (hPDLSCs) were investigated.

resultsThe experimental composites achieved flexural strengths of 67.9 to 50.1 MPa (

conclusionsThese findings suggest that this novel composite possesses potent antibacterial activity, acceptable cytocompatibility, and adequate mechanical properties, making it promising for multifunctional root caries restorations.

Indexed as

antibacterial compositeDMAHDMhPDLSCsmetforminperiodontal tissue regenerationroot cariesstem cells

Identifiers

PMID42513701
PMCPMC13412206

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.