Evidence map›Paper›PMID 42514006›Full record

ArticleMicroorganisms2026

Combined High Hydrostatic Pressure and Additive Chemical Treatment Enhances Decontamination Efficiency in Bone Tissue Infected with Staphylococcal Biofilms.

Henrike Loeffler, Adam Bieda, Martina Sombetzki, Ralf-Joerg Fischer, Mirko Basen, Karoline Schulz, Janine Waletzko, Rainer Bader, Annett Klinder

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Henrike LoefflerBiomechanics and Implant Technology Research Laboratory, Department of Orthopedics, Orthopedic Clinic and Polyclinic, Rostock University Medical Center, 18057 Rostock, Germany.ORCID 0009-0006-1959-9924
Adam BiedaDepartment for Internal Medicine, Clinic and Polyclinic for Infectious Diseases, Nephrology, Endocrinology and Tropical Medicine, Rostock University Medical Center, 18057 Rostock, Germany.
Martina SombetzkiDepartment for Internal Medicine, Clinic and Polyclinic for Infectious Diseases, Nephrology, Endocrinology and Tropical Medicine, Rostock University Medical Center, 18057 Rostock, Germany.
Ralf-Joerg FischerMicrobiology, Institute of Biological Sciences, University of Rostock, 18059 Rostock, Germany.ORCID 0000-0003-0522-3206
Mirko BasenMicrobiology, Institute of Biological Sciences, University of Rostock, 18059 Rostock, Germany.ORCID 0000-0002-1001-9245
Karoline SchulzMedical Biology and Electron Microscopy Centre, Rostock University Medical Center, 18057 Rostock, Germany.
Janine WaletzkoBiomechanics and Implant Technology Research Laboratory, Department of Orthopedics, Orthopedic Clinic and Polyclinic, Rostock University Medical Center, 18057 Rostock, Germany.
Rainer BaderBiomechanics and Implant Technology Research Laboratory, Department of Orthopedics, Orthopedic Clinic and Polyclinic, Rostock University Medical Center, 18057 Rostock, Germany.
Annett KlinderBiomechanics and Implant Technology Research Laboratory, Department of Orthopedics, Orthopedic Clinic and Polyclinic, Rostock University Medical Center, 18057 Rostock, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteomyelitis remains one of the most persistent challenges in orthopedic and trauma surgery, often requiring removal of infected bone tissue segments and leaving critical size defects. Reimplantation of sterilized autologous bone may combine optimal anatomical fit with biological compatibility. This study investigates sodium dodecyl sulfate (SDS) and ethylenediaminetetraacetic acid (EDTA) in combination with high hydrostatic pressure (HHP) as a physicochemical sterilization approach for

Indexed as

bone grafthigh hydrostatic pressureosteomyelitisStaphylococcus aureusStaphylococcus epidermidissterilization

Identifiers

PMID42514006
PMCPMC13414376

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.