ArticleNutrients2026
Effect of a Polysaccharide from Cultivated
Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
backgroundIn this study, a cultivated mushroom (
methodsThe protective effect of BSP60 on ulcerative colitis (UC) was evaluated using a dextran sulphate sodium (DSS)-induced murine model of UC.
resultsThe results showed that BSP60 significantly alleviated colonic inflammation and oxidant stress in DSS-treated mice. BSP60 reduced the overproduction of TNF-α, IL-1β, and IL-6; lowered the accumulation of MDA and LPS in serum and colon; and increased the activities of antioxidant enzymes SOD and GSH-Px in colonic tissues. Histological observations revealed that BSP60 significantly alleviated DSS-induced colonic tissue damage in mice by reducing inflammatory cell infiltration and mucosal injury. Immunofluorescence staining revealed that BSP60 increased the expression of intestinal barrier-associated proteins ZO-1, occludin, and claudin-1 in DSS-induced UC mice, thereby alleviating inflammation. Analysis of 16S rRNA gene sequencing indicated that BSP60 maintained gut microbiota homeostasis in UC mice and inhibited the excessive growth of inflammation-associated microorganisms. BSP60 also enhanced the production of short-chain fatty acids in the mice feces. The protective effect of BSP60 on UC was dose dependent.
conclusionsBSP60 exerts anti-UC effects, providing a scientific basis for its application as a functional food ingredient to improve intestinal health.
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