Evidence map›Paper›PMID 42514381›Full record

ArticleNutrients2026

Early-Life High-Fat Diet Impairs Autophagy and Reduces GABA

Muzi Qian, Ogula Doubra, Yadi Su, Shuyu Bai, Han Zhou, Hong Li, Dongying Yan, Liang Gao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Muzi QianSchool of Public Health, Jinzhou Medical University, Jinzhou 121001, China.
Ogula DoubraSchool of Public Health, Jinzhou Medical University, Jinzhou 121001, China.
Yadi SuSchool of Public Health, Jinzhou Medical University, Jinzhou 121001, China.
Shuyu BaiSchool of Public Health, Jinzhou Medical University, Jinzhou 121001, China.
Han ZhouSchool of Public Health, Jinzhou Medical University, Jinzhou 121001, China.
Hong LiSchool of Public Health, Jinzhou Medical University, Jinzhou 121001, China.
Dongying YanSchool of Public Health, Jinzhou Medical University, Jinzhou 121001, China.ORCID 0000-0002-9201-8237
Liang GaoSchool of Public Health, Jinzhou Medical University, Jinzhou 121001, China.ORCID 0000-0001-5731-8616

Funding

Basic Scientific Research Project of the Education Department of Liaoning Province LJ212410160066Department of Science and Technology of Liaoning Province 2025-MSLH-216Natural Science Foundation of Liaoning Province 2022-BS-314
6 · The paper itself

Abstract

backgroundsEarly-life nutritional excess increases the risk of depressive-like phenotypes in offspring, yet the underlying mechanisms remain unclear. This study investigated whether perinatal and adolescent high-fat diet (HFD) exposure is associated with depressive-like behaviors through disruption of the autophagy-GABARAP pathway in hypothalamic neurons.

methodsA mouse model of HFD exposure during both periods was established. Depressive-like behaviors, hypothalamic autophagic flux, and GABARAP-GABA

resultsHFD exposure induced metabolic disturbances and depressive-like behaviors, suppressed autophagic flux (p62 and LC3-II accumulation), increased GABARAP-GABA

conclusionsImpaired autophagic flux correlates with reduced GABA

Indexed as

AutophagyBehavior, AnimalDepressionDiet, High-FatHypothalamusNeuronsReceptors, GABA-AAdaptor Proteins, Signal TransducingAnimalsApoptosis Regulatory ProteinsCells, CulturedDevelopmental Origins of Health and DiseaseDisease Models, AnimalFemaleMaleMiceAdaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsGABARAP protein, mouseMicrotubule-Associated ProteinsReceptors, GABA-Aautophagy–GABARAP pathwaydepressive-like behaviorGABAA receptorhigh-fat diethypothalamic neurons

Identifiers

PMID42514381
PMCPMC13431247

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.