The NLRP3 Inflammasome as a Central Driver of Mastitis Pathogenesis: A Review.

Shuaishuai Wu, Mohamed Tharwat, Ibrahim F Halawani, Fuad M Alzahrani, Khalid J Alzahrani, Muhammad Zahoor Khan

Abstract readReview

In one paragraph

Review in Veterinary sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shuaishuai WuCollege of Animal Science and Technology, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China.

Mohamed TharwatDepartment of Clinical Sciences, College of Veterinary Medicine, Qassim University, P.O. Box 6622, Buraidah 51452, Saudi Arabia.ORCID 0000-0002-3796-9590

Ibrahim F HalawaniDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID 0000-0001-6632-0646

Fuad M AlzahraniDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID 0000-0001-6930-5214

Khalid J AlzahraniDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.ORCID 0000-0002-6688-0106

Muhammad Zahoor KhanCollege of Agriculture and Biology, Liaocheng University, Liaocheng 252000, China.ORCID 0000-0001-5890-2996

Funding

Key Technology Research Project of Henan Province 232102111047

6 · The paper itself

Abstract

Mastitis remains the most economically damaging disease of dairy production, and recent molecular work has converged on the NLRP3 inflammasome as a key integrative node of its pathogenesis. This narrative review integrates evidence published largely between 2015 and 2026 to show how diverse triggers-

Indexed as

blood–milk barriergut–mammary axismastitisNLRP3 inflammasomepharmacological inhibitionpyroptosis

Identifiers

PMID42514619

DOI10.3390/vetsci13070609

PMCPMC13417066

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.