Evidence map›Paper›PMID 42514683›Full record

ArticleVeterinary sciences2026

The Cytopathogenic BVDV Core Protein Binds with ASC-Enhance the Assembly of Inflammasome Complex and GSDMD-Mediated Pyroptosis.

Ning He, Hongming Zhou, Jiaming Yang, Jiying Yin, Qi Wang, Zitong Jing, Yang Liu, Yuxin Kong, Fanli Zeng, Jianming Li and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ning HeCollege of Animal Medicine, College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China.
Hongming ZhouAgriculture College, Yanbian University, Yanji 133002, China.
Jiaming YangCollege of Animal Medicine, College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China.
Jiying YinCollege of Animal Medicine, College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China.
Qi WangCollege of Animal Medicine, College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China.
Zitong JingCollege of Animal Medicine, College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China.
Yang LiuCollege of Animal Medicine, College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China.
Yuxin KongAgriculture College, Yanbian University, Yanji 133002, China.
Fanli ZengCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Jianming LiCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Naichao DiaoCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Kun ShiCollege of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Rui DuAgriculture College, Yanbian University, Yanji 133002, China.

Funding

Jilin Province Science and Technology Department 20230101255JCNational Natural Science Foundation of China 32573352
6 · The paper itself

Abstract

Bovine viral diarrhea virus (BVDV) infection is associated with inflammatory responses, but the mechanisms underlying inflammasome activation remain unclear. In this study, Madin-Darby bovine kidney (MDBK) cells were used to compare the inflammatory responses induced by the cytopathogenic NADL strain and the non-cytopathogenic TC strain. Both strains significantly increased IL-1β and IL-18 production and promoted NLRP3 inflammasome assembly, indicating activation of upstream inflammasome signaling. However, only the NADL strain markedly induced Gasdermin D (GSDMD) cleavage, membrane pore formation, lactate dehydrogenase release, and pyroptotic cell death. Further mechanistic analyses demonstrated that the NADL core protein C interacted with the inflammasome adaptor ASC, thereby facilitating NLRP3 inflammasome assembly and enhancing inflammatory cytokine secretion. Silencing ASC significantly impaired inflammasome activation and pyroptosis induced by protein C, confirming its essential role in this process. Collectively, these findings demonstrate that the cytopathogenic BVDV NADL strain activates ASC-dependent NLRP3 inflammasome signaling and GSDMD-mediated pyroptosis through its core protein C, providing a molecular explanation for the distinct inflammatory responses and pathogenic outcomes associated with different BVDV biotypes.

Indexed as

ASCbovine viral diarrhea virusNLRP3 inflammasomepyroptosis

Identifiers

PMID42514683
PMCPMC13431418

What Socratic holds

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.